TerminatedEarly Phase 1ACTRN12616001075471

Quantifying the Clinical Benefit of Magnetic Resonance Imaging (MRI) in Lung Cancer Radiotherapy

Quantifying the Clinical Benefit of MRI in Lung Cancer Radiotherapy

Sponsor

Liverpool Cancer Therapy Centre

Enrollment

36 participants

Start Date

Oct 29, 2013

Study Type

Interventional

Conditions

Lung Cancer

Summary

This study aims to quantify clinical benefit of Magnetic resonance imaging (MRI) during lung cancer radiotherapy. Who is it for? Participants aged 18 years or over and have histological or cytological confirmed lung cancer scheduled to be treated with 12 or more fractions of treatment. Study details: All participants in this study will undergo MRI scans in addition to standard scans used during radiotherapy treatment (CT and PET). Participant of this trial will undergo a total of six MRI scans which will be performed before radiotherapy treatment starts, and at treatment day 1, day 11 and day 21 (where applicable), and three and six months post treatment completion. MRI scans acquired will not alter or impact participant’s treatment intent.This study will not impact on the participants standard treatment.

Eligibility

Sex: Both males and femalesMin Age: 18 Yearss

Inclusion Criteria3

Histological or cytological confirmed lung cancer
Patient has good renal function ( GFR < 53ml/min)
Patient is receiving 12 or more fractions of treatment

Exclusion Criteria2

Contraindication to MRI
Prior surgery to area of treatment

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Interventions

There is no direct intervention to patients standard treatment. During the course radiotherapy, participants will receive MRI scans at specified time points to identify changes during the course of t

There is no direct intervention to patients standard treatment. During the course radiotherapy, participants will receive MRI scans at specified time points to identify changes during the course of treatment, A total of 6 MRI scans to be performed. Scan 1 is performed at least 1 week prior to the start of treatment. Scan 2 is performed on Day 1 of treatment. Subsequent scans are performed on day 11 and 21 during treatment. Follow up MRI scans at 3months and 6 months post treatment. Participants PET and CT scans acquired as part standard radiotherapy planning will be utilised as well. MRI images acquired for this study will not impact of change treatment intent for participants. All images will be utilised retrospectively.