A Clinical Trial to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of PRAX-944 in Essential Tremor

Essential tremor is a neurological condition that causes involuntary shaking, most often in the hands and arms. It can make everyday tasks like writing, eating, or holding a cup difficult. While some medications exist to help manage tremor, they don't work well for everyone and can have side effects. PRAX-944 is a new investigational drug being tested to see if it can reduce tremor more effectively. This Phase 2 trial tests the safety, tolerability, and effectiveness of PRAX-944 over a 3–4 week treatment period. Participants will attend clinic visits during a screening period, the treatment period, and a safety follow-up period. Blood samples will be taken to understand how the drug moves through the body. You may be eligible if you are aged 18–75 with a confirmed diagnosis of essential tremor, either taking a stable dose of one tremor medication or no tremor medications at all. People with other neurological conditions that could cause tremor, those who have had brain surgery or deep brain stimulation for tremor, or those unable to stop taking primidone are not eligible.