Topical Modification of Dental Pain and Movement

Wisdom tooth extraction is a very common procedure, but it often causes significant pain, swelling, and difficulty opening the mouth for several days afterwards. The nerves involved in dental pain express specific receptors (TRPV1, TRPA1, TRPM3) that can be targeted with topical treatments. This study tests two topical products — a spray and a cream — that target these receptors, to see whether they can reduce pain and improve jaw mobility after wisdom tooth surgery compared to a placebo. Participants undergoing the removal of wisdom teeth on both sides of the mouth receive the topical products and are assessed for pain levels and how wide they can open their jaw in the days following surgery. The bilateral extraction design means the same person experiences the surgery on both sides, providing a useful comparison. You may be eligible if you are 14 or older and are scheduled to have both your left and right wisdom teeth removed. People with a known intolerance or allergy to the product ingredients, or who have intellectual disabilities or do not speak English, are not eligible.