CompletedPhase 2ACTRN12619001645145

Genicular Nerve Block for Pain Management in Patients with Knee Osteoarthritis: A Randomised Double-blind Placebo Controlled Trial

Genicular Nerve Block for Pain Management in Patients with Knee Osteoarthritis: A Randomised Control Trial

Sponsor

Rheumatology Department, Flinders Medical Centre

Enrollment

60 participants

Start Date

Jul 9, 2020

Study Type

Interventional

Conditions

Osteoarthritis of the knee

Summary

Knee Osteoarthritis affects many people, causing significant pain and immobility. At present, there are very few effective treatments available to managing pain in patients with osteoarthritis. This study is designed to investigate a new treatment, called a 'Genicular nerve block'. This study aims to demonstrate that 'Genicular nerve block' is a safe and effective method for treating knee osteoarthritis.

Eligibility

Sex: Both males and femalesMin Age: 18 Yearss

Inclusion Criteria2

Adults aged 18 yo or older of either sex with knee OA referred for knee replacement surgery
Participants must have knee OA as per ACR classification criteria and chronic knee pain with pain intensity of at least 4/10 on the VAS on most or all days for > 3 months

Exclusion Criteria6

Patients with systemic inflammatory joint disease
Allergy to local anaesthetic
Pregnant women
Patients who have undergoing an intra-articular corticosteroid injection to the affected knee/s 3 months prior to enrolment
Patients who are likely to be non-compliant with follow up
Patients who will be unable to provide written informed consent

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Interventions

Assess for reduction of pain in patients with knee OA when treated with Genicular nerve block compared to placebo. The interventional procedure will be performed by a consultant Radiologist or Rheumatologist who is experienced in administering Genicular nerve blocks under ultrasound guidance. Intervention Patient will be positioned supine with a pillow under the popliteal fossa for comfort Under Ultrasound guidance the superior lateral genicular nerve, superior medial genicular nerve, and inferior medial genicular nerve will by identified by using the corresponding artery as a guide Under sterile non touch technique with 1ml lidocaine 2% local anaesthetic each nerve will be infiltrated with 5.7mg celestone chronodose (1ml) + 3mL 0.5% bupivacaine at each target site The study will be conducted at Flinders Medical Centre The procedure is expected to take approximately 30 minutes Patients will receive a single Genicular nerve block, and then outcome measures will be recorded at a number of time intervals for 12 weeks following the procedure.