Bacterial evolution during golden staph infections
Bacterial Adaptation during Invasive Staphylococcus aureus infections
University of Melbourne
200 participants
May 1, 2021
Observational
Conditions
Summary
BARISTA is a prospective, multi-centre bacterial genomics study of invasive Staphylococcus aureus infections that is currently recruiting the Austin Hospital and Royal Melbourne Hospital in Melbourne. Adult patients admitted for a monomicrobial sterile site infection (eg. blood, bone, or joint) are included, with up to a year follow-up. The study collects all clinical samples with growth of S. aureus (blood cultures but also bone, muscle, joint), and samples from recurrent infections within a year. Nasal swabs are collected at enrolment and after 6 and 12 months and in case of recurrence. EDTA blood is collected to extract cell-free DNA (cf-DNA).
Eligibility
Inclusion Criteria3
- Age greater or equal to 18 years
- Admitted to a participating centre
- Invasive S. aureus infection (at least 1 sterile sample with growth of S. aureus [e.g. blood, valve, bone])
Exclusion Criteria3
- Polymicrobial infection at time of inclusion
- Treating team deems enrolment in the study is not in the best interest of the patient
- Death is deemed to be imminent and inevitable within the next 48 hours
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Interventions
Invasive S. aureus infection (at least 1 sterile sample with growth of S. aureus [e.g. blood, valve, bone]) admitted at Austin and Royal Melbourne Hospitals in Melbourne, Victoria Following samples are collected: 1. At enrolment and during the initial admission: - all clinical samples with growth of S. aureus: blood cultures, tissue biopsies (e.g. bone, muscle), body liquids (e.g. joint fluid), pus from abscesses. These samples are already collected for clinical reasons, no additional intervention required - a nasal swab (collected by a registered nurse) - a 9 ml blood sample at enrolment, after 3 days and after 7 days (collected by a registered nurse) 2. At follow-up at 6 and 12 months after enrolment: - nasal swab (self collection) 3. At infection recurrence within 12 months: - all clinical samples with growth of S. aureus: blood cultures, tissue biopsies (e.g. bone, muscle), body liquids (e.g. joint fluid), pus from abscesses. These samples are already collected for clinical reasons, no additional intervention required - a nasal swab (collected by a registered nurse) - a 9 ml blood sample at enrolment, after 3 days and after 7 days (collected by a registered nurse)
Locations(2)
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ACTRN12623001222639