Sepsis Clinical Trials

263 recruitingLast updated: June 17, 2026

There are 263 actively recruiting sepsis clinical trials across 64 countries. Studies span Not Applicable, Phase 2, Phase 4, Phase 3, Phase 1, Early Phase 1. Top locations include Philadelphia, Pennsylvania, United States, Shanghai, Shanghai Municipality, China, Guangzhou, Guangdong, China. Updated daily from ClinicalTrials.gov.


Sepsis Trials at a Glance

263 actively recruiting trials for sepsis are listed on ClinicalTrialsFinder across 6 cities in 64 countries. The largest study group is Not Applicable with 54 trials, with the heaviest enrollment activity in Philadelphia, Shanghai, and Guangzhou. Lead sponsors running sepsis studies include Children's Hospital of Fudan University, Assistance Publique - Hôpitaux de Paris, and Ain Shams University.

Treatments under study

About Sepsis Clinical Trials

Looking for clinical trials for Sepsis? There are currently 233 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Sepsis trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Sepsis clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 263 trials

Recruiting
Not Applicable

Veno-arterial Carbon Dioxide Partial Pressure Difference (CO2gap) for Early Resuscitation of Septic Shock

Septic ShockSepsis - to Reduce Mortality in the Intensive Care Unit
University Hospital, Clermont-Ferrand750 enrolled28 locationsNCT07179276
Recruiting

ICU Combined Assessment of Cardio-Respiratory Exercise

ICU acquired weaknessmicrocirculationSepsis+2 more
University of Manitoba50 enrolled2 locationsNCT06193980
Recruiting
Phase 2

Prospective, Randomized Trial of Personalized Medicine With Pentaglobin® After Surgical Infectious Source Control in Patients With Peritonitis

SepsisSeptic ShockPeritonitis
RWTH Aachen University200 enrolled20 locationsNCT03334006
Recruiting
Phase 1

A Study to Learn About How Safe BAY 3389934 is, Its Suitable Dose, and How it Affects the Participants With Sepsis Induced Coagulopathy

coagulopathySepsis
Bayer36 enrolled20 locationsNCT06854640
Recruiting

Smart Discharges for Older Children

Sepsis
University of British Columbia4,000 enrolled7 locationsNCT07629154
Recruiting

Evaluation of the Performance of the IDBIORIV Method in Pathogen Identification and Antibiotic Susceptibility Testing in Patients With Sepsis

Sepsis
Hospices Civils de Lyon1,372 enrolled23 locationsNCT06219135
Recruiting

Sepsis Multiomic Analysis & Risk sTratification in China

Sepsis
Yuebei People's Hospital1,400 enrolled1 locationNCT07599644
Recruiting

Extended Interval Dosing of Gentamicin in Neonates

Early-onset Sepsis
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's42 enrolled1 locationNCT07460349
Recruiting
Phase 1Phase 2

Labile Iron Removal by Adding the Iron Chelator MEX-CD1 to Dialysate in Sepsis-Associated Acute Kidney Injury

SepsisAcute Kidney Injury
Centre Hospitalier Universitaire de Nīmes14 enrolled2 locationsNCT07236463
Recruiting

Clinical Microbial Species & Antibiotic Resistance ID in ED Patients Presenting With Infection - is Rapid ID Possible & Accurate?

SepsisSystemic Inflammatory Response SyndromeInfection, Bacterial+5 more
Michigan State University2,500 enrolled2 locationsNCT01904188
Recruiting
Phase 4

Eduction in ImmunoSuppressive Regimen Among Kidney Transplant Recipients Patients Admitted to the Intensive Care Unit for Septic Shock and/or Acute Respiratory Failure

Acute Respiratory FailureKidney Transplant RecipientsSepsis and septic shock+1 more
University Hospital, Strasbourg, France212 enrolled1 locationNCT06881927
Recruiting
Phase 2

Adjunctive Fludrocortisone in Septic Shock

SepsisSeptic ShockSepsis and septic shock+2 more
Chinese University of Hong Kong32 enrolled5 locationsNCT07451886
Recruiting

MIRNA QUANTIFICATION IN PATIENTS WITH SEPTIC SHOCK

Sepsis and septic shock
Insel Gruppe AG, University Hospital Bern56 enrolled1 locationNCT07597122
Recruiting

Recovery of Physical Function After Critical Illness In Older Adults

SepsisAcute Lung Injury(ALI)
University of Kentucky150 enrolled1 locationNCT07225257
Recruiting
Phase 2

Combination Cefazolin With Ertapenem for Methicillin-susceptible Staphylococcus Aureus Bacteremia

Staphylococcus Aureus BacteremiaStaphylococcus Aureus EndocarditisStaphylococcus Aureus Septicemia+1 more
Todd C. Lee MD MPH FIDSA60 enrolled6 locationsNCT04886284
Recruiting

Prognostic Value of Right Ventricular-pulmonary Arterial Coupling Assessed by Echocardiography in Septic Patients

Sepsis
University Medical Center Ho Chi Minh City (UMC)215 enrolled1 locationNCT06887140
Recruiting
Phase 2

Corticosteroids in Hyperinflammatory Phenotype of Critical Illness

SepsisAcute Respiratory Distress Syndrome
Bin Du150 enrolled1 locationNCT07511582
Recruiting
Phase 2

MID-STEP (MIDodrine for Sepsis Treatment and Early vasoPressor Weaning) Trial

SepsisLow blood pressure
Mayo Clinic308 enrolled5 locationsNCT06319248
Recruiting
Phase 2

An Acupuncture Study for People At High Risk for Sepsis

Sepsis
Memorial Sloan Kettering Cancer Center78 enrolled1 locationNCT06344819
Recruiting

Sulbactam-Durlobactam in CRAB Infection: A Real-World Cohort Study

bloodstream infectionSepsisPneumonia+1 more
Sichuan Provincial People's Hospital200 enrolled1 locationNCT07601711