RecruitingPhase 4ACTRN12623001309673

The Utility of Pericapsular Nerve Group (PENG) Block versus Intrathecal Morphine for Postoperative Analgesia in Anterior Approach Total Hip Arthroplasty: A Multicentre Triple Blinded Randomised Controlled Trial


Sponsor

Tim Cheok

Enrollment

70 participants

Start Date

Feb 17, 2025

Study Type

Interventional

Conditions

Summary

Multimodal pain relief forms part of the early rehabilitation protocol in patients undergoing hip replacement. This has been shown to reduce complications and improve outcomes. The pericapsular nerve group (PENG) block is a new type of regional nerve block, which is associated with fewer side effects, than the currently used intrathecal morphine. Its efficacy in providing pain relief has not been demonstrated in anterior hip replacement. The primary aim of our project is to compare the postoperative pain relief provided by these techniques, at 3- and 24-hours following surgery, in patients undergoing anterior hip replacement. The secondary aim of our project is to compare the side effect profile, opioid utilisation, time to mobilisation, hospital length of stay, standardised patient reported outcome measures (PROMs) and patient satisfaction.


Eligibility

Sex: Both males and femalesMin Age: 18 Yearss

Plain Language Summary

Simplified for easier understanding

Hip replacement surgery (total hip arthroplasty) is one of the most common and successful operations performed in Australia, but managing pain afterwards is critical for early recovery and rehabilitation. Currently, many patients undergoing hip replacement via the anterior (front) approach receive a spinal injection of morphine (intrathecal morphine) for pain relief. While effective, this can cause side effects like nausea, itching, and urinary retention. A newer technique called the PENG (pericapsular nerve group) block uses a targeted injection of local anaesthetic around the hip joint capsule. It appears to provide good pain relief with fewer side effects, but its effectiveness for anterior hip replacement specifically has not been well tested in a head-to-head comparison. This multicentre randomised controlled trial is comparing PENG block to intrathecal morphine in adults undergoing elective anterior hip replacement under spinal anaesthesia. The main questions are: which technique provides better pain relief at 3 and 24 hours after surgery, and which has a better side effect profile? Eligible participants are all adults presenting for this specific procedure who can provide informed consent and are able to have spinal anaesthesia.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PENG Group: The block will be placed using ultrasound guidance with a curvilinear probe (2.5-5 MHz). 20 mL of ropivacaine 0.5% (100 mg) prepared by the anaesthesiologist performing the block will be u

PENG Group: The block will be placed using ultrasound guidance with a curvilinear probe (2.5-5 MHz). 20 mL of ropivacaine 0.5% (100 mg) prepared by the anaesthesiologist performing the block will be used. The area is aseptically prepped and draped. The curvilinear probe will be placed transversely, medial to the anterior inferior iliac spine with the medial end of the probe rotated in a caudad direction to align to the superior pubic ramus. A 100 mm Sonoplex needle will be inserted in-plane under ultrasound guidance. 20 mLs of local anaesthetic (ropivacaine) will be injected as a plane block between the psoas fascia and superior pubic rami. A cross shall then be drawn on the skin with surgical marker to disguise the presence of a puncture site. Adherence will be monitored by auditing of anaesthesia records


Locations(1)

SA, Australia

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