Dietary and lifestyle predictors of pouchitis
Longitudinal study of diet, lifestyle and biomarker predictors of pouchitis
Monash University
82 participants
Jan 11, 2024
Observational
Conditions
Summary
Pouchitis is the most common inflammatory condition for those living with an ileoanal pouch (whereby the large bowel is removed due to medically unresponsive ulcerative colitis (UC) or familial adenomatous polyposis (FAP) and its cause is largely unknown. We aim to assess whether specific diet components and psychological factors such as stress can predict pouchitis. We also aim to assess whether faecal calprotectin (a marker of inflammation found in faeces) can be used as a test to predict worsening in pouch function or pouchitis. This study will follow patients with an ileoanal pouch prospectively for 18 months to evaluate if diet, stress and faecal calprotectin play a role in predicting pouchitis or worsening of pouchitis. This is important because there are currently no dietary guidelines to help ileoanal pouch patients.
Eligibility
Inclusion Criteria6
- Living with an ileoanal pouch
- -75 years old
- Living in Australia,
- Ability to speak and read English
- Eligible for Medicare
- Internet access
Exclusion Criteria2
- Chronic antibiotic refractory pouchitis (pouchitis refractory to combination antibiotics for greater than or equal to 4 weeks)
- Inability to provide informed consent
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Interventions
We will be following individuals with an ileoanal pouch over 18 months to identify if dietary factors or psychological stress are environmental factors that can predict the onset or worsening of pouchitis. Participants will complete 3-day food diaries, complete a series of online questionnaires related to their pouch function and stress as well as collecting biological samples. Data will be collected online every 6 months, and biological samples will be collected at home and posted back to researchers. Secondly, from the data we collected, we will be assessing how useful faecal calprotectin can be used as a prognostic marker for the development or worsening of pouchitis. In order to achieve this, we will be collecting information about what participants eat, how their pouch functions, their stress levels and psychological wellbeing. Faecal calprotectin in their stools will be collected and hair samples as a retrospective way of looking at the stress hormone, cortisol to identify chronic stress. Dietary intake will be assessed on its overall ‘healthfulness’ and used to find underlying relationships with pouchitis.
Locations(1)
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ACTRN12624000016538