Anorectal Chlamydia Trachomatis infection in asymptomatic women
Prevalence of anorectal Chlamydia Trachomatis infection in asymptomatic urogenital Chlamydia Trachomatis positive women who present to regional North Queensland Sexual Health Services.
James Cook University
290 participants
Apr 12, 2024
Interventional
Conditions
Summary
We want to find out how many women who test positive for Chlamydia Trachomatis infection in the urogenital region, are also infected in anal canal (back passage) . This study focuses on women who have no symptoms of infection and have had no anal sexual contact in the past six months. This is because, symptoms of chlamydia often do not show up in women. Also, anal canal chlamydia can be present when the vagina or urethra are infected, even when a woman has not participated in any anal sexual contact, and at this time we do not know how many women are cross infected in this way. This research help us understand how much anal chlamydia may be present in women infected with urogenital chlamydia but have no symptoms and no history of anal sexual contact. This is important as the medications used to treat the CT in the two different anatomical regions is different. ie the treatment for urogenital CT is not as effective as the optimal treatment for ano rectal CT. The research will help us to make any necessary policy changes to improve chlamydia detection and treatment, because if women with no symptoms are not tested correctly, this can result in several unpleasant health problems, with spread of infection to sexual partners and any unborn children the woman may carry. The study hypothesis is that In a North Queensland population of women with urogenital CT who are asymptomatic and report no previous anal sexual contact, 50% will test positive for concurrent anorectal CT (based on an estimate from data from a previous international study [Van Liere et al.,2014]).
Eligibility
Inclusion Criteria6
- Community dwelling women (>18 yrs)
- Asymptomatic for any symptoms that may indicate a possible STI
- Positive for urogenital CT, identified by a swab test conducted at one of the two SHS sites in the previous 48 hours but having not commenced treatment for CT.
- Report no ASC (anal: penetration, contact with fingers, and/or sex toys, or oral contact) in the previous six months.
- Willing, and able to understand and complete all procedures related to their ‘usual clinical care’.
- Willing, and able to understand and provide written informed consent to participate in the study.
Exclusion Criteria10
- Individuals who report any symptoms indicative of a STI including but not limited to:
- Dysuria,
- Dyspareunia,
- Vaginal or rectal discharge,
- Pelvic or rectal pain,
- Intermenstrual, post coital, or rectal bleeding
- Individuals who have already commenced treatment for the current chlamydia infection
- Inability or unwillingness to provide written consent.
- Men, or men who are transitioning to women
- Transgender or gender diverse people
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Interventions
This prospective study will investigate and report the rates of confirmed anorectal chlamydia trachomatis (CT) infection in women who attend one of two regional North Queensland sexual health services (SHS). The research will focus on women who are confirmed to have urogenital CT infection following routine testing at the SHS, but they report no symptoms of CT prior to testing, and have not participated in any anal sexual contact in the previous six months. Participants would receive access to anal swab testing for anal CT which is not routinely given to asymptomatic women who are routinely tested for urogenital CT. Findings have potential to influence future testing and management guidelines for management of CT in this group of women. The anal swab will be conducted immediately following enrolment into the study and within 48hrs of a positive urogenital swab test (routine care). Only a single anal swab will be conducted.
Locations(2)
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ACTRN12624000471583