RecruitingACTRN12624000471583

Anorectal Chlamydia Trachomatis infection in asymptomatic women

Prevalence of anorectal Chlamydia Trachomatis infection in asymptomatic urogenital Chlamydia Trachomatis positive women who present to regional North Queensland Sexual Health Services.


Sponsor

James Cook University

Enrollment

290 participants

Start Date

Apr 12, 2024

Study Type

Interventional

Conditions

Summary

We want to find out how many women who test positive for Chlamydia Trachomatis infection in the urogenital region, are also infected in anal canal (back passage) . This study focuses on women who have no symptoms of infection and have had no anal sexual contact in the past six months. This is because, symptoms of chlamydia often do not show up in women. Also, anal canal chlamydia can be present when the vagina or urethra are infected, even when a woman has not participated in any anal sexual contact, and at this time we do not know how many women are cross infected in this way. This research help us understand how much anal chlamydia may be present in women infected with urogenital chlamydia but have no symptoms and no history of anal sexual contact. This is important as the medications used to treat the CT in the two different anatomical regions is different. ie the treatment for urogenital CT is not as effective as the optimal treatment for ano rectal CT. The research will help us to make any necessary policy changes to improve chlamydia detection and treatment, because if women with no symptoms are not tested correctly, this can result in several unpleasant health problems, with spread of infection to sexual partners and any unborn children the woman may carry. The study hypothesis is that In a North Queensland population of women with urogenital CT who are asymptomatic and report no previous anal sexual contact, 50% will test positive for concurrent anorectal CT (based on an estimate from data from a previous international study [Van Liere et al.,2014]).


Eligibility

Sex: FemalesMin Age: 18 Yearss

Plain Language Summary

Simplified for easier understanding

Chlamydia is one of the most common sexually transmitted infections, and in women it often causes no symptoms at all, making it easy to miss. What many people don't know is that chlamydia can infect not just the genitals and urinary tract, but also the anal canal — even in women who have never had anal sex. This matters because the medications most commonly used to treat genital chlamydia are less effective at clearing the infection from the anal canal. This study, based in North Queensland, aims to find out how many women who have tested positive for genital chlamydia also have an undetected infection in the anal canal, despite having no symptoms and no history of anal sexual contact. Participants will have an additional anal swab taken as part of their routine clinical care. You may be eligible if you are a woman aged 18 or older, are asymptomatic (no signs of infection), have tested positive for urogenital chlamydia in the last 48 hours but have not yet started treatment, and have not had anal sexual contact in the past 6 months. Women who already have symptoms of an STI or who have started treatment are not eligible.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

This prospective study will investigate and report the rates of confirmed anorectal chlamydia trachomatis (CT) infection in women who attend one of two regional North Queensland sexual health services

This prospective study will investigate and report the rates of confirmed anorectal chlamydia trachomatis (CT) infection in women who attend one of two regional North Queensland sexual health services (SHS). The research will focus on women who are confirmed to have urogenital CT infection following routine testing at the SHS, but they report no symptoms of CT prior to testing, and have not participated in any anal sexual contact in the previous six months. Participants would receive access to anal swab testing for anal CT which is not routinely given to asymptomatic women who are routinely tested for urogenital CT. Findings have potential to influence future testing and management guidelines for management of CT in this group of women. The anal swab will be conducted immediately following enrolment into the study and within 48hrs of a positive urogenital swab test (routine care). Only a single anal swab will be conducted.


Locations(2)

Townsville Sexual Health Services - North Ward

QLD, Australia

Mackay Base Hospital - Mackay

QLD, Australia

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ACTRN12624000471583


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