From risk to response: recognising and responding to family domestic and sexual violence in Multiple Sclerosis (MS) and broader neurology

Family, domestic, and sexual violence exposure is assessed once at enrolment through structured screening and once via validated surveys post-enrolment. Retrospective MSBase and clinical data (EDSS, relapses, MRI, comorbidities, neuropsychology scores, medications) are collected at enrolment to capture prior disease course. Prospective MS outcomes are then recorded through routine MSBase and clinical follow-up every 3–12 months for 3 years. Qualitative interviews are conducted once per participant. a) Condition/exposure The study observes people with Multiple Sclerosis (MS) and examines exposure to family, domestic, and sexual violence (FDSV). b) Observational data collected Data captured includes MS outcomes (EDSS, relapses, MRI), comorbidities, neuropsychology scores, medications, and prospectively recorded clinical data every 3–12 months. Retrospective data will also be collected from prior outpatient visits documented in the MSBase database. c) Procedures for participants Participants are not required to undertake any additional clinical procedures beyond their usual outpatient neurology visits. The study involves collation of routinely recorded clinical data supplemented by standardised surveys/questionnaires where relevant. d) Frequency and duration of observation Data is collected prospectively at routine visits every 3–12 months over a three-year period. Retrospective data will be extracted from existing medical records in MSBase and outpatient records prior to enrolment. Retrospective data Retrospective data includes MS outcomes (EDSS, relapses, MRI findings), comorbidities, neuropsychology scores, and medication history recorded at prior outpatient neurology visits. This information will be extracted from the MSBase database and site clinical records.