RecruitingACTRN12626000308392

The CAMAS Study: A Cross-sectional magnetic resonance imaging study on the myocardial effects of long-term anaerobic exercise using structure-function correlation

A Cross-sectional magnetic resonance imaging study on the myocardial effects of long-term anaerobic exercise using structure-function correlation in active adults


Sponsor

The University of Sydney

Enrollment

40 participants

Start Date

Jan 27, 2026

Study Type

Observational

Conditions

Summary

The CAMAS study is a prospective, longitudinal observational cohort study examining the effects of long-term anaerobic exercise on myocardial structure and function. Adults with predominantly anaerobic gym training are compared with individuals undertaking predominantly aerobic exercise using cardiac magnetic resonance imaging (CMR) and electrocardiography. Blood samples are collected for exploratory molecular analyses where funding permits. Participants are followed annually for up to ten years to document cardiac diagnoses and cardiovascular events. The study aims to identify imaging-based phenotypes associated with anaerobic exercise and potential cardiovascular risk.


Eligibility

Sex: Both males and femalesMin Age: 18 Yearss

Plain Language Summary

Simplified for easier understanding

The CAMAS Study is investigating what long-term gym-based (anaerobic) exercise does to the heart compared to endurance-based (aerobic) exercise like running or cycling. While the heart benefits of aerobic exercise are well established, much less is known about how years of weightlifting and resistance training shape the heart's structure and function — and whether there are any hidden risks. Participants will undergo cardiac MRI scans and ECGs to produce detailed images of their heart, along with optional blood tests. The study will follow participants annually for up to ten years to track any changes and record any cardiovascular events or diagnoses over time. This long-term view will help researchers identify whether certain heart patterns seen in gym athletes are benign adaptations or potential warning signs. You may be eligible if you are 18 or older and have trained regularly (at least 3 sessions per week for at least 5 years) in either predominantly gym-based or endurance-based exercise. You are not eligible if you have known heart disease, a recent significant COVID-19 illness, a family history of cardiomyopathy, or any implants that are incompatible with MRI scanning.

This is a simplified summary. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

The CAMAS study is a prospective, longitudinal observational exposure study (no intervention). Participants are enrolled based on exercise exposure: a) Exposure group (anaerobic): adults (at least

The CAMAS study is a prospective, longitudinal observational exposure study (no intervention). Participants are enrolled based on exercise exposure: a) Exposure group (anaerobic): adults (at least 18 years) with approximately 5 years of predominantly anaerobic gym training (at least 3 days/week, at least 120 min/week, including at least 1 lower body session/week); anaerobic group additionally requires ability to bench press and squat at least their body weight (kg). All enrolled participants undergo a baseline research assessment comprising a questionnaire (anticipated to take approximately 10-15 minutes); 12-lead digital ECG, venous blood sampling, and cardiac MRI (CMR) (approximately 1 hour). Participants are followed annually for up to 10 years to capture interim cardiac diagnoses and cardiovascular events.


Locations(1)

NSW, Australia

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ACTRN12626000308392


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