A Prospective Database of Infants With Cholestasis

This study builds a database to track infants with cholestasis (a condition where bile doesn't flow properly from the liver) and suspected biliary atresia (a blockage of the bile ducts). Researchers want to better understand the causes, progression, and outcomes of these rare liver diseases in newborns. You may be eligible if: - Your infant is 6 months old or younger at the time of first presentation at a participating clinic - Your infant has elevated direct or conjugated bilirubin (≥2 mg/dL) with suspected biliary atresia - You (the parent/guardian) are willing to provide written informed consent You may NOT be eligible if: - Your infant has acute liver failure - Your infant has had prior hepatobiliary surgery involving removal of bile duct tissue - Your infant has bacterial or fungal sepsis, hypoxia/shock within the past 2 weeks, a diagnosed malignancy, primary hemolytic disease, drug- or TPN-associated cholestasis, or ECMO-associated cholestasis - Your infant's birth weight was less than 1,500 grams (unless biliary atresia is diagnosed) Talk to your doctor to see if this trial is right for you.