RecruitingNCT00181259

Magnetic Resonance Spectroscopy Studies of Cardiac Muscle Metabolism

In Vivo Cardiac Metabolism in Normal, Ischemic, and Cardiomyopathic Patients During Rest and Stress

Sponsor

Johns Hopkins University

Enrollment

500 participants

Start Date

Jan 1, 1988

Study Type

OBSERVATIONAL

Conditions

Heart Failure, Congestive

Summary

The metabolism of the heart provides the chemical energy needed to fuel ongoing normal heart contraction. Magnetic resonance spectroscopy is a technique used in a MRI scanner that can be used to measure and study heart metabolism directly but without blood sampling or obtaining tissue biopsies. One of the hypotheses this study aims to investigate is whether energy metabolism is reduced in heart failure and whether that contributes to the poor heart function.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study uses a special type of MRI scan (magnetic resonance spectroscopy) to measure energy levels in heart muscle cells, comparing healthy hearts with those affected by heart disease. **You may be eligible if...** - You are over 18 years of age - You are a healthy volunteer with no history of heart disease, OR - You have dilated cardiomyopathy (a weakened, enlarged heart) with an ejection fraction below 40%, OR - You have left ventricular hypertrophy (a thickened heart wall above 1.2 cm), OR - You have coronary artery disease with a significant blockage or a positive stress test **You may NOT be eligible if...** - You have a contraindication to MRI (such as certain metal implants or a pacemaker) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(1)

Johns Hopkins Medical Institutions

Baltimore, Maryland, United States

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NCT00181259

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