RecruitingNCT00181259
Magnetic Resonance Spectroscopy Studies of Cardiac Muscle Metabolism
In Vivo Cardiac Metabolism in Normal, Ischemic, and Cardiomyopathic Patients During Rest and Stress
Sponsor
Johns Hopkins University
Enrollment
500 participants
Start Date
Jan 1, 1988
Study Type
OBSERVATIONAL
Conditions
Summary
The metabolism of the heart provides the chemical energy needed to fuel ongoing normal heart contraction. Magnetic resonance spectroscopy is a technique used in a MRI scanner that can be used to measure and study heart metabolism directly but without blood sampling or obtaining tissue biopsies. One of the hypotheses this study aims to investigate is whether energy metabolism is reduced in heart failure and whether that contributes to the poor heart function.
Eligibility
Min Age: 18 Years
Inclusion Criteria5
- age \> 18 years
- Healthy subjects: no history of heart disease
- Dilated cardiomyopathy: history of heart failure, ejection fraction (EF) \<40%
- Left ventricular hypertrophy: wall thickness \>1.2cm
- Coronary artery disease: \>50% coronary lesion or positive stress test
Exclusion Criteria1
- contraindication to MRI
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT00181259
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