RecruitingPhase 4NCT06218199

Diuretics vs. Afterload Reduction for Treatment of HeartLogic Alerts

Diuretics vs. Afterload Reduction for Treatment of HeartLogic Alerts (DART-HA)


Sponsor

Heart Center Research, LLC

Enrollment

80 participants

Start Date

Jul 8, 2021

Study Type

INTERVENTIONAL

Conditions

Summary

The DART-HA study is a single-center, open label, trial intended to evaluate the clinical efficacy of standard treatment options for congestive heart failure (observation, diuretic or afterload reduction therapy) in patients without new symptoms who have developed abnormalities of the HeartLogic heart failure diagnostic feature.


Eligibility

Min Age: 19 Years

Plain Language Summary

Simplified for easier understanding

This trial is comparing two approaches for managing early warning signs of worsening heart failure detected by a smart implanted heart device (HeartLogic alert): increasing diuretics (water pills) versus adding or adjusting afterload-reducing medication (sacubitril/valsartan) that reduces strain on the heart. The goal is to determine which approach better prevents hospitalization. **You may be eligible if...** - You have a Boston Scientific implanted heart device with HeartLogic monitoring enabled - You are not on dialysis and have reasonable kidney function - Your blood pressure is above 105 mmHg systolic - You are able to tolerate either treatment option **You may NOT be eligible if...** - Your kidney filtration rate is below 25 mL/min and you don't respond to diuretics, or you are on dialysis - You are currently experiencing worsening heart failure symptoms (increased breathlessness or fatigue) - You had a significant change in heart rhythm problems in the past 2 weeks - You are pregnant or planning to become pregnant - You are already receiving regular IV heart failure medications - You are scheduled for a heart transplant or ventricular assist device within 6 months Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGFurosemide

oral administration

DRUGTorsemide

oral administration

DRUGBumetanide

oral administration

DRUGsacubitril/valsartan

oral administration

DRUGHydralazine

oral administration

DRUGIsosorbide Dinitrate

oral administration


Locations(1)

Heart Center Research, LLC

Huntsville, Alabama, United States

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NCT06218199


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