SCOPE: Observational Study of the Consequences of the Protease Inhibitor Era

This observational study (SCOPE) is following HIV-positive adults over time to understand how HIV progresses differently in different people — including those who naturally control the virus without treatment. **You may be eligible if...** - You are HIV-positive with a viral load under 2,000 copies/mL without being on HIV treatment - You are HIV-positive, on a stable treatment regimen, but your CD4 count has been consistently below 350 for 12 months - You are HIV-positive and treatment-naive, planning to start antiretroviral therapy - You have been HIV-positive for at least 10 years with no treatment in the last 10 years and a consistently high CD4 count (long-term non-progressor) **You may NOT be eligible if...** - You have an active serious infection (other than mild oral thrush) - You are currently being treated for cancer - You are receiving interferon-based treatment for hepatitis C - You have taken immunosuppressive medications in the last 4 months Talk to your doctor to see if this trial is right for you.