Evaluation of Stool Based Markers for the Early Detection of Colorectal Cancers and Adenomas

This study is testing whether stool (poop) samples can detect early signs of colorectal cancer or precancerous polyps, by comparing special stool markers against colonoscopy results. **You may be eligible if...** - You are at least 18 years old - You are willing to provide 1–2 stool samples and a stool blood test (FIT) - You fall into one of these groups: you have colorectal cancer not yet treated, you have precancerous polyps (adenomas), you have a personal or family history of colon cancer or polyps, or you are at average risk with no history of colon problems - Pregnant or nursing women may participate if they otherwise qualify **You may NOT be eligible if...** - You have had surgery, radiation, or chemotherapy for your current colorectal cancer before providing samples - You have active inflammatory bowel disease (Crohn's or ulcerative colitis) - You have hereditary colon cancer syndromes (HNPCC or FAP) - You are unable to give informed consent - You have another active cancer (diagnosed within the past 3 years) - You are on active chemotherapy or radiation for any condition - You have HIV or chronic active hepatitis - You are pregnant - You are having a virtual colonoscopy (CT colonography) Talk to your doctor to see if this trial is right for you.