RecruitingNCT01034033

Genetic & Pathological Studies of BRCA1/BRCA2: Associated Tumors & Blood Samples

Sponsor

Stanford University

Enrollment

3,300 participants

Start Date

Aug 1, 2001

Study Type

OBSERVATIONAL

Conditions

Breast Cancer Gynecologic Cancers Ovarian Cancer Ovarian/Peritoneal/Fallopian Cancer

Summary

The purpose of this study is to try to understand the biology of development of breast, ovarian, fallopian tube, peritoneal or endometrial cancer from persons at high genetic risk for these diseases. The influence of environmental factors on cancer development in individuals and families will be studied. The efficacy of treatments for these diseases will be evaluated.

Eligibility

Sex: FEMALEMin Age: 18 Years

Inclusion Criteria2

I. Women who have a high risk of developing breast or ovarian cancer due to a known germline mutation in the BRCA1/2, PTEN, CDH1, or TP53 cancer susceptibility genes, or due to strong family history of either breast or ovarian cancer, in the absence of known cancer susceptibility gene mutation.
II. Women who are approaching surgery for resection of a pelvic mass, which is considered suspicious for neoplasia by radiologic or clinical criteria; such women may or may not also meet criteria for inclusion in group I.