RecruitingNCT01212003

Training Protocol on the Natural History of Tuberculosis

Natural History of Tuberculosis

Sponsor

National Institute of Allergy and Infectious Diseases (NIAID)

Enrollment

150 participants

Start Date

Jun 30, 2011

Study Type

OBSERVATIONAL

Conditions

Tuberculosis Latent Tuberculosis Mycobacterium Infections Tuberculosis, Multidrug-Resistant Extensively Drug-Resistant Tuberculosis

Summary

Background: \- Tuberculosis (TB) is an infectious disease that affects numerous people worldwide. Researchers are interested in actively recruiting individuals with TB for research and treatment studies. Objectives: \- To collect blood and other samples to study the natural history of tuberculosis. Eligibility: \- Individuals 2 years of age and older who have either active or latent tuberculosis. Design: * Latent TB patients: Participants will have a single study visit with a physical examination and medical history, and will provide blood samples for testing. * Active TB patients: Participants will have an initial visit with a physical examination and medical history, and will provide blood samples for testing. Participants will also provide sputum samples if required, and may have an optional skin punch biopsy to collect a sample of skin tissue for study. * Treatment for active TB will be provided as part of this protocol. * Active TB participants may be asked to return for study visits every 1-2 months while receiving treatment.

Eligibility

Min Age: 2 YearsMax Age: 100 Years

Plain Language Summary

Simplified for easier understanding

This training and natural history study follows people who have — or are suspected to have — tuberculosis (TB), either active or latent (inactive). It is run at the National Institutes of Health (NIH) and is designed to help medical trainees learn about TB while also collecting research data on how the disease progresses and responds to treatment. Participants must have their own doctor who manages their TB care outside NIH. You may be eligible if... - You have or are suspected to have TB infection (latent or active), of any drug-susceptibility pattern - You have a positive TB skin test (PPD) or IGRA blood test for latent TB - You are 2 years of age or older - You have a primary care, infectious disease, or TB specialist outside of NIH who can manage your treatment - You are able to provide informed consent (or have a legal representative do so) You may NOT be eligible if... - You are currently incarcerated or have been court-ordered to take TB medications - You are unwilling to comply with prescribed therapy - You are pregnant - You are under 2 years of age Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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