Tuberculosis Clinical Trials

77 recruiting

Tuberculosis Trials at a Glance

138 actively recruiting trials for tuberculosis are listed on ClinicalTrialsFinder across 6 cities in 59 countries. The largest study group is Not Applicable with 34 trials, with the heaviest enrollment activity in Kampala, Cape Town, and Cape Town. Lead sponsors running tuberculosis studies include Johns Hopkins University, University of California, San Francisco, and Huashan Hospital.

Browse tuberculosis trials by phase

Treatments under study

About Tuberculosis Clinical Trials

Looking for clinical trials for Tuberculosis? There are currently 77 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Tuberculosis trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Tuberculosis clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 138 trials

Recruiting

Paradoxical Tuberculosis Reactions in Patients Without HIV Infection

Tuberculosis
National Institute of Allergy and Infectious Diseases (NIAID)140 enrolled2 locationsNCT04052022
Recruiting
Phase 2

Bactericidal Activity of TBD09 in Combination With Other Drugs in Pulmonary Tuberculosis

Drug Susceptible Pulmonary Tuberculosis
Gates Medical Research Institute150 enrolled13 locationsNCT07525427
Recruiting
Phase 2Phase 3

Shorter and Safer Treatment Regimens for Latent TB

Tuberculosis Infection, Latent
McGill University Health Centre/Research Institute of the McGill University Health Centre1,800 enrolled13 locationsNCT06498414
Recruiting

Quantitative Measurement of Plasma and Urine MTB Cell-free DNA Level

Tuberculosis
Chinese University of Hong Kong85 enrolled2 locationsNCT07170735
Recruiting
Phase 2

Bactericidal Activity and Safety of Nicotinamide in Combination With Bedaquiline, Pretomanid, and Linezolid in Drug-susceptible Pulmonary Tuberculosis

Drug Susceptible Pulmonary Tuberculosis
Gates Medical Research Institute165 enrolled4 locationsNCT07517445
Recruiting

Training Protocol on the Natural History of Tuberculosis

TuberculosisLatent TuberculosisMycobacterium Infections+2 more
National Institute of Allergy and Infectious Diseases (NIAID)150 enrolled1 locationNCT01212003
Recruiting
Phase 2

Trial of Novel Regimens for the Treatment of Pulmonary Tuberculosis

Pulmonary Tuberculosis
National Institute of Allergy and Infectious Diseases (NIAID)315 enrolled29 locationsNCT06192160
Recruiting
Phase 2

Pharmacokinetic Study to Evaluate Anti-mycobacterial Activity of TMC207 in Combination With Background Regimen (BR) of Multidrug Resistant Tuberculosis (MDR-TB) Medications for Treatment of Children/Adolescents With Pulmonary MDR-TB

Tuberculosis, Multidrug-Resistant
Janssen Research & Development, LLC60 enrolled11 locationsNCT02354014
Recruiting

Immunogenicity of COVID-19 Vaccines in Tuberculosis Patients

TuberculosisCovid-19 Pandemics
University of Oxford133 enrolled1 locationNCT05571735
Recruiting

Blood Tuberculosis DNA Levels to Monitor Tuberculosis Treatment

Tuberculosis, PulmonaryMycobacterium TuberculosisTuberculosis, Extra-Pulmonary
University of Oxford140 enrolled1 locationNCT06845618
Recruiting
Phase 3

Shortened Regimen for Drug-susceptible TB in Children

TuberculosisTuberculosis, PulmonaryMycobacterium Tuberculosis+1 more
Johns Hopkins University860 enrolled9 locationsNCT06253715
Recruiting
Not Applicable

South Africa Smoking Cessation and Engagement in HIV/TB Care Care

HIV InfectionsSmoking CessationTuberculosis
Massachusetts General Hospital86 enrolled1 locationNCT05842161
Recruiting

18F-Fibroblast Activation Protein Inhibitor (18F-FAPI-74) in Tuberculosis Patients

Tuberculosis, Pulmonary
Children's Hospital Medical Center, Cincinnati30 enrolled1 locationNCT07077213
Recruiting
Phase 2

A Study to Evaluate the Efficacy, Safety and Immunogenicity of MTBVAC in Adolescents and Adults Living in a TB Endemic Region.

Tuberculosis (TB)
International AIDS Vaccine Initiative5,500 enrolled16 locationsNCT06272812
Recruiting

Diagnostic Utility of Mycobacterium Tuberculosis Cell-free DNA

Tuberculosis, Pleural
Chinese University of Hong Kong400 enrolled1 locationNCT06439810
Recruiting
Not Applicable

Parent Study Name: Pulmonary Rehabilitation to Reduce Post-Tuberculosis Morbidity (TB Pure)

TB - TuberculosisTBTB Infection
Johns Hopkins University690 enrolled2 locationsNCT07164742
Recruiting
Phase 1

Study of a Single Dose of Pretomanid Added to an Optimized Background Regimen in Children With Rifampicin-Resistant Tuberculosis

TuberculosisRifampicin Resistant Tuberculosis
National Institute of Allergy and Infectious Diseases (NIAID)72 enrolled6 locationsNCT05586230
Recruiting
Not Applicable

The DECIDE-TB Trial; Validation of Treatment Decision Algorithms for Childhood Tuberculosis

TuberculosisHIVChild Health+1 more
Chishala Chabala30,240 enrolled29 locationsNCT06593080
Recruiting
Not Applicable

Peer-led Implementation of TB-HIV Education and Adherence Counseling in Uganda

TuberculosisHIV
Yale University1,920 enrolled1 locationNCT05917210
Recruiting
Not Applicable

Effects of the Active Cycle of Breathing Technique With and Without Balloon Blowing Therapy in Tuberculosis

Tuberculosis
Riphah International University34 enrolled1 locationNCT07484490