Islet Transplantation in Type 1 Diabetic Kidney Allograft

This study transplants insulin-producing islet cells (from a donor pancreas) into Type 1 diabetic patients who have already received a kidney transplant, with the goal of restoring the body's ability to produce insulin naturally. **You may be eligible if...** - You are between 18 and 68 years old with Type 1 diabetes diagnosed before age 40, and have been insulin-dependent for more than 5 years - Your body no longer produces any insulin (confirmed by a specific blood test) - You have received a kidney transplant at least 3 months ago and have stable kidney function - You are already taking immunosuppression medication to protect your kidney transplant **You may NOT be eligible if...** - You weigh more than 90 kg or have a BMI above 30 - You require very high or very low doses of insulin - You have received other organ transplants (besides kidney or a failed pancreas) - You have uncontrolled diabetic eye disease, high blood pressure, or poor kidney function - You are pregnant, breastfeeding, or plan to become pregnant - You have active hepatitis B, hepatitis C, HIV, or tuberculosis Talk to your doctor to see if this trial is right for you.