ClinicalTrialsFinder
RecruitingNCT01351545

A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)

A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs) for Transplantation in Pediatric and Adult Patients With Hematologic Malignancies and Other Indications

Sponsor

Center for International Blood and Marrow Transplant Research

Enrollment

99,999 participants

Start Date

Oct 1, 2011

Study Type

OBSERVATIONAL

Conditions

Hematologic MalignanciesInherited Disorders of MetabolismInherited Abnormalities of PlateletsHistiocytic DisordersAcute Myelogenous Leukemia (AML or ANLL)

Summary

This study is an access and distribution protocol for unlicensed cryopreserved cord blood units (CBUs) in pediatric and adult patients with hematologic malignancies and other indications.

Eligibility

Plain Language Summary

Simplified for easier understanding

This protocol provides access to cord blood units (umbilical cord blood stem cells) from unlicensed donors for patients who need a stem cell transplant to treat inherited or acquired blood and bone marrow disorders. **You may be eligible if...** - You are a child or adult of any age with a blood or bone marrow disorder that is inherited, acquired (such as leukemia or aplastic anemia), or resulted from prior cancer treatment - You have signed informed consent **You may NOT be eligible if...** - All the cord blood units you need are already licensed (only unlicensed units are provided through this protocol) - You are receiving your transplant at an international center - You are enrolled in another research protocol for accessing unlicensed cord blood - The cord blood units would be more than minimally manipulated beyond standard processing Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DRUGA multicenter access and distribution protocol for unlicensed cryopreserved cord blood units (CBUs)

A multicenter access and distribution protocol for unlicensed cryopreserved cord blood units (CBUs) for transplantation in pediatric and adult patients with hematologic malignancies and other indications

Locations(142)

University of Alabama at Birmingham

Birmingham, Alabama, United States

Banner MD Anderson Cancer Center

Gilbert, Arizona, United States

Phoenix Children's Hospital

Phoenix, Arizona, United States

Mayo Clinic Arizona (adults)

Phoenix, Arizona, United States

University of Arizona Medical Center - Tucson

Tucson, Arizona, United States

Arkansas Children's Hospital

Little Rock, Arkansas, United States

City of Hope

Duarte, California, United States

Children's Hospital of Los Angeles

Glendale, California, United States

Scripps Green Hospital

La Jolla, California, United States

University of California San Diego

La Jolla, California, United States

Loma Linda University Cancer Center

Loma Linda, California, United States

UCLA

Los Angeles, California, United States

Children's Hospital and Research Center of Oakland

Oakland, California, United States

Children's Hospital of Orange County (CHOC)

Orange, California, United States

Sutter Medical Center

Sacramento, California, United States

Rady Children's Hospital San Diego

San Diego, California, United States

UCSF (adults)

San Francisco, California, United States

UCSF (Peds)

San Francisco, California, United States

Stanford University Medical Center

Stanford, California, United States

Children's Hospital Colorado

Aurora, Colorado, United States

University of Colorado Hospital

Aurora, Colorado, United States

Presbyterian St. Luke's/Colorado Blood Cancer Institute

Denver, Colorado, United States

Yale New Haven Hospital

New Haven, Connecticut, United States

Nemours - Alfred I. duPont Hospital for Children

Brandywine, Delaware, United States

Children's National Medical Center

Washington D.C., District of Columbia, United States

University of Florida Shands Medical Center

Gainesville, Florida, United States

Nemours Children's Hospital - Mayo Jacksonville

Jacksonville, Florida, United States

Mayo Clinic - Jacksonville

Jacksonville, Florida, United States

University of Miami (adult)

Miami, Florida, United States

University of Miami (peds)

Miami, Florida, United States

Niklaus Children's Hospital

Miami, Florida, United States

AdventHealth Orlando

Orlando, Florida, United States

Florida Center for Pediatric Cellular Therapy

Orlando, Florida, United States

Orlando Health Arnold Palmer Hospital for Children

Orlando, Florida, United States

Orlando Health Cancer Institute Bone Marrow Transplant and Cellular Therapy

Orlando, Florida, United States

All Children's Hospital

St. Petersburg, Florida, United States

H Lee Moffitt Cancer Center

Tampa, Florida, United States

Children's Healthcare of Atlanta

Atlanta, Georgia, United States

Emory University Hospital

Atlanta, Georgia, United States

Northside Hospital

Atlanta, Georgia, United States

Georgia Cancer Center at Augusta University Health

Augusta, Georgia, United States

Kapiolani Medical Center for Women and Children

Honolulu, Hawaii, United States

Northwestern Memorial Hospital

Chicago, Illinois, United States

Rush University Medical Center

Chicago, Illinois, United States

University of Illinois at Chicago

Chicago, Illinois, United States

Ann & Robert H. Lurie Children's Hospital of Chicago

Chicago, Illinois, United States

University of Chicago

Chicago, Illinois, United States

Loyola University Medical Center

Maywood, Illinois, United States

Advocate Lutheran General Hospital

Park Ridge, Illinois, United States

Midwestern Regional Medical Center

Zion, Illinois, United States

Indiana Blood & Marrow Transplantation

Beech Grove, Indiana, United States

Indiana University/Riley Hospital for Children

Indianapolis, Indiana, United States

University of Iowa

Iowa City, Iowa, United States

University of Kansas

Westwood, Kansas, United States

University of Louisville Hospital - James Brown Cancer Center

Louisville, Kentucky, United States

Tulane Medical Center

New Orleans, Louisiana, United States

Children's Hospital of New Orleans/LSUHSC

New Orleans, Louisiana, United States

Greenebaum Cancer Center - University of Maryland

Baltimore, Maryland, United States

Johns Hopkins

Baltimore, Maryland, United States

Nih/Niaid

Bethesda, Maryland, United States

NIH/NCI

Bethesda, Maryland, United States

Nih/Nhlbi

Bethesda, Maryland, United States

Tufts Medical Center

Boston, Massachusetts, United States

Massachusetts General Hospital

Boston, Massachusetts, United States

Beth Israel Deaconess

Boston, Massachusetts, United States

Dana Farber Cancer Institute

Boston, Massachusetts, United States

University of Massachusetts

Worcester, Massachusetts, United States

University of Michigan

Ann Arbor, Michigan, United States

Children's Hospital of Michigan

Detroit, Michigan, United States

Karmanos Cancer Institute

Detroit, Michigan, United States

Henry Ford Health System

Detroit, Michigan, United States

Helen DeVos Children's Hospital

Grand Rapids, Michigan, United States

Spectrum Health

Grand Rapids, Michigan, United States

Mayo Clinic Rochester

Rochester, Minnesota, United States

Univeristy of Mississippi Medical Center

Jackson, Mississippi, United States

Children's Mercy Hospital and Clinics

Kansas City, Missouri, United States

Cardinal Glennon Children's Medical Center

St Louis, Missouri, United States

St. Louis University Medical Center

St Louis, Missouri, United States

Washington University St. Louis

St Louis, Missouri, United States

Washington University/St. Louis Children's Hospital

St Louis, Missouri, United States

University of Nebraska Medical Center

Omaha, Nebraska, United States

Hackensack University Medical Center

Hackensack, New Jersey, United States

Robert Wood Johnson/Cancer Institute of New Jersey

New Brunswick, New Jersey, United States

Roswell Park Cancer Institute

Buffalo, New York, United States

North Shore University Hospital

Lake Sucess, New York, United States

Cohen Children's Medical Center of New York

New Hyde, New York, United States

New York University Langone Medical Center

New York, New York, United States

New York Presbyterian Hospital at Cornell

New York, New York, United States

Mount Sinai Medical Center - New York

New York, New York, United States

Columbia University Medical Center - Morgan Stanley Children's Hospital

New York, New York, United States

Memorial Sloan-Kettering Cancer Center

New York, New York, United States

Westchester Medical Center

New York, New York, United States

Strong Memorial Hospital/University of Rochester

Rochester, New York, United States

Stony Brook University Hospital

Stony Brook, New York, United States

Children's Hospital at Montefiore

The Bronx, New York, United States

University of North Carolina at Chapel Hill

Chapel Hill, North Carolina, United States

Levine Children's Hospital

Charlotte, North Carolina, United States

Duke University Medical Center

Durham, North Carolina, United States

Wake Forest University

Winston-Salem, North Carolina, United States

Childrens Hospital Medical Center of Akron

Akron, Ohio, United States

Cincinnati Children's Hospital

Cincinnati, Ohio, United States

The Jewish Hospital

Cincinnati, Ohio, United States

University Hospitals Case Medical Center

Cleveland, Ohio, United States

Cleveland Clinic

Cleveland, Ohio, United States

Nationwide Children's Hospital

Columbus, Ohio, United States

The Arthur G. James Cancer Hospital/The Ohio State University Medical Center

Columbus, Ohio, United States

University of Oklahoma Health Science Center

Oklahoma City, Oklahoma, United States

Oregon Health & Science University/Doernbecher Children's Hospital

Portland, Oregon, United States

Penn State Milton S. Hershey Cancer Center

Hershey, Pennsylvania, United States

Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, United States

Children's Hospital of Pittsburgh

Pittsburgh, Pennsylvania, United States

West Penn Hospital

Pittsburgh, Pennsylvania, United States

University of Pittsburgh Medical Center

Pittsburgh, Pennsylvania, United States

University of Pennsylvania/Thomas Jefferson

Pittsburgh, Pennsylvania, United States

Roger Williams Medical Center

Providence, Rhode Island, United States

Medical University of South Carolina

Charleston, South Carolina, United States

Avera Transplant Institute

Sioux Falls, South Dakota, United States

Methodist Healthcare Blood and Marrow Transplant Center

Memphis, Tennessee, United States

St. Jude Childrens Research Hospital

Memphis, Tennessee, United States

Sarah Cannon BMT Program

Nashville, Tennessee, United States

VA Tennessee Valley Healthcare System

Nashville, Tennessee, United States

Vanderbilt University

Nashville, Tennessee, United States

Amarillo Blood and Marrow Transplant Program

Amarillo, Texas, United States

Medical City Dallas

Dallas, Texas, United States

Children's Medical Center Dallas

Dallas, Texas, United States

University of Texas Southwestern Medical Center

Dallas, Texas, United States

Zachary & Elizabeth Fisher Bone Marrow Transplant Program (Brooke Army Medical Center)

Fort Sam Houston, Texas, United States

Cook Children's Hospital

Fort Worth, Texas, United States

M.D. Anderson Cancer Center

Houston, Texas, United States

Texas Children's Hospital - Baylor Medical Center

Houston, Texas, United States

Southwest Cancer Treatment & Research Center

Lubbock, Texas, United States

The Children's Hospital of San Antonio

San Antonio, Texas, United States

Methodist Healthcare System of San Antonio/Texas Transplant Institute

San Antonio, Texas, United States

University of Utah

Salt Lake City, Utah, United States

University of Virginia

Charlottesville, Virginia, United States

Virginia Commonwealth University

Richmond, Virginia, United States

VA Puget Sound HCS

Seattle, Washington, United States

Fred Hutchinson Cancer Research Center

Seattle, Washington, United States

West Virginia University

Morgantown, West Virginia, United States

University of Wisconsin - Madison

Madison, Wisconsin, United States

Children's Hospital of Wisconsin

Milwaukee, Wisconsin, United States

Medical College of Wisconsin

Milwaukee, Wisconsin, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT01351545

Related Trials

Trial of Allogeneic Reduced-Intensity, HLA-Haploidentical Allogeneic Hematopoietic Cell Bone Marrow Transplantation Followed by Graft-versus-Host-Disease (GVHD) Prophylaxis With Cyclophosphamide, Bortezomib and Maraviroc for Hematologic Malignancies ...

NCT054704911 location

Study of SLS009 (Formerly GFH009) a Potent Highly Selective CDK9 Inhibitor in Patients With Hematologic Malignancies and High-Risk Newly Diagnosed AML

NCT0458892225 locations

Phase I Trial Integrating HLA-Haploidentical Anti-CD19 CAR-T Cells With Post-Transplantation Cyclophosphamide-Based HLA-Haploidentical Hematopoietic Cell Transplantation

NCT071620381 location

Optimized Cord Blood Transplantation for the Treatment of Patients With High-risk Hematologic Malignancies Who Have Relapsed After First Allogeneic Stem Cell Transplantation

NCT068076061 location

Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)

NCT03486873779 locations