RecruitingNCT01580982

Molecular Analysis of Oncogenes and Resistance Mechanisms in Lung Cancer

Molecular Analysis of Oncogenes and Resistance Mechanisms in Lung and Other Thoracic Cancers

Sponsor

University of Colorado, Denver

Enrollment

500 participants

Start Date

Jan 23, 2012

Study Type

OBSERVATIONAL

Conditions

Lung Neoplasms

Summary

The mechanisms of sensitivity and resistance to oncogene-targeted therapy can be determined from tumor tissue or tumor cell lines derived from available archival samples and/or from standard-of-care re-biopsy upon suspected tumor progression.

Eligibility

Min Age: 18 YearsMax Age: 85 Years

Inclusion Criteria4

Patients undergoing investigation or treatment for thoracic cancers with oncogene-targeted therapies
Aged 18 years or older
Either a) have suspected tumor progression or other condition that dictates a standard-of-care palliative, therapeutic, or diagnostic intervention including but not limited to procedures such as bronchoscopic biopsy, computed tomography (CT) or ultra-sound (US)-guided biopsy, thoracentesis, video assisted thoracoscopic (VATS) pleurodesis, lobectomy, adrenalectomy or pleural catheter placement, providing tumor specimen appropriate molecular analysis or b) have previously had biopsy/surgical intervention with tumor tissue at University of Colorado or an outside institution available for medullar analysis.
Patients must have the ability to understand and willingness to sign an informed consent document.