Islet Transplantation in Patients With "Brittle" Type I Diabetes

This study is testing whether transplanting insulin-producing cells (called islets) from donor pancreases into people with extremely difficult-to-control Type 1 diabetes — known as 'brittle' diabetes — can stabilize blood sugar levels and reduce dangerous episodes of very low blood sugar. **You may be eligible if...** - You are between 18 and 70 years old - You have had Type 1 diabetes since before age 40 and have been insulin-dependent for at least 5 years - Your pancreas produces no measurable insulin on its own (confirmed by a specific test) - You have 'brittle' diabetes, meaning your blood sugar is very difficult to control despite best efforts - You are able to understand and follow the study procedures **You may NOT be eligible if...** - You are outside the age range of 18 to 70 - You still produce some of your own insulin - You have significant kidney disease, heart disease, or other conditions that make the procedure unsafe - You are pregnant or planning to become pregnant Talk to your doctor to see if this trial is right for you.