Effects of Treatments on Atopic Dermatitis

This study investigates how different treatments — including antibiotics and bleach baths — affect the skin bacteria and immune responses in people with atopic dermatitis (eczema) and in healthy volunteers, to develop better therapies for eczema. You may be eligible if: - You are aged 2–50 years with diagnosed moderate-to-severe atopic dermatitis and signs of bacterial skin infection, or - You are a healthy adult volunteer aged 18–50 years (for comparison cohorts) - You are also co-enrolled in the related NIH protocol 08-HG-0059 (for some cohorts) You may NOT be eligible if: - You are pregnant or breastfeeding - You have a known immune deficiency or HIV - You have used systemic antibiotics in the past 12 months (for healthy volunteers) - You have a history of eczema or asthma (for healthy volunteer cohorts) - You have used systemic antibiotics within 8 weeks (for eczema patients) - You are receiving or plan to receive immunosuppressants, biologics, or UV therapy - You smoke or use tobacco products - You are a perimenopausal or menopausal woman (for some cohorts) Talk to your doctor to see if this trial is right for you.