Domperidone in Treating Patients With Gastrointestinal Disorders

This study provides access to domperidone — a medication that helps the stomach empty properly — for patients with gastrointestinal motility disorders (such as gastroparesis, severe acid reflux, or dyspepsia) who have not responded to standard treatments. You may be eligible if: - You are 16 years of age or older - You have gastroparesis, refractory GERD (persistent heartburn or reflux), or severe dyspepsia - You have failed standard therapies for these conditions - You have adequate blood counts and organ function You may NOT be eligible if: - You have a heart condition including prolonged QTc interval, arrhythmias, heart failure, or ischemic heart disease - You take antiarrhythmic drugs or MAO inhibitors - You have a history of active liver failure - You have significant electrolyte imbalances - You had GI bleeding or obstruction in the past 6 weeks - You have a prolactin-secreting pituitary tumour - You are pregnant or breastfeeding - You are allergic to domperidone Talk to your doctor to see if this trial is right for you.