RecruitingNot ApplicableNCT01786590

Endobronchial Ultrasound-guided Transbronchial Needle Aspiration for Lymph Node Staging in Patients With Non-small Cell Lung Cancer Pursuing Stereotactic Body Radiotherapy (SBRT)

Sponsor

University Health Network, Toronto

Enrollment

150 participants

Start Date

Feb 1, 2013

Study Type

INTERVENTIONAL

Conditions

Lung Cancer

Summary

It is reported that more than 90,000 patients died of lung cancer and more than 20% of them were older than 80 years in North America. Therefore a less invasive but effective treatment is required for patients with lung cancer of advanced age, diminished pulmonary functions, and chronic diseases. Stereotactic body radiation therapy (SBRT) is an effective and well-tolerated treatment for early stage lung cancer in medically inoperable patients. On the other hand, accurate mediastinal and hilar lymph node staging is one of the most important factors that determine the outcome and indications for SBRT. Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a novel, minimally invasive modality that enables the assessment of mediastinal and hilar lymph nodes with a high sensitivity. Accurate lymph node staging by EBUS-TBNA will allow opportunities for high-risk patients with lung cancer to undergo minimally invasive treatment.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study evaluates a procedure called EBUS-TBNA (a scope that uses ultrasound to sample lymph nodes in the chest) to check whether lung cancer has spread to nearby lymph nodes before giving focused radiation treatment (SBRT). **You may be eligible if...** - You have confirmed non-small cell lung cancer (NSCLC) that is stage T1–T2 (small to medium-sized tumor with no distant spread) - You need lymph node assessment before receiving stereotactic body radiation therapy (SBRT) - You are 18 or older and in reasonably good health - You are unable to have surgery, or you have chosen not to have surgery **You may NOT be eligible if...** - You are medically unfit for a bronchoscopy (breathing tube camera procedure) - You have an active infection in your lungs or the lining around your heart - You are pregnant or breastfeeding - You plan to receive standard chemotherapy, surgery, or conventional radiation instead of SBRT Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREEBUS-TBNA

Currently EBUS-TBNA is performed in patients with CT and/or PET positive lymph nodes in the mediastinum or hilum. In this study, all patients being considered for SBRT will undergo EBUS-TBNA for the lymph node staging prior to SBRT.