Genetics of Insulin and Incretins in Cystic Fibrosis
Evaluation of the Enteroinsular Axis in Cystic Fibrosis
Children's Hospital of Philadelphia
550 participants
May 1, 2013
OBSERVATIONAL
Conditions
Summary
Cystic fibrosis related diabetes (CFRD) is associated with worse CF-relevant outcomes. The mechanisms underlying CFRD development are not fully understood, but recent evidence suggests Type 2 Diabetes Mellitus (T2DM) mechanisms may be involved and may involve incretins (gut secreted hormones that augment insulin secretion in response to a nutrient load). This study will examine the prevalence of Genome wide association study (GWAS)-implicated T2DM alleles (including TCF7L2) across the spectrum of glucose abnormalities in CF and will use this information to compare incretin and insulin secretion in non-diabetic children and adults with high risk and low risk alleles.
Eligibility
Inclusion Criteria3
- Subjects age >2y
- Diagnosis of Cystic Fibrosis
- For subjects< 18 years, parental/guardian permission (informed consent) and if appropriate, child assent
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Interventions
A blood or saliva sample will be obtained for genotyping of TCF7L2 and approximately ten other genes implicated in type 2 diabetes.
Locations(2)
View Full Details on ClinicalTrials.gov
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NCT01852448