Hormonal, Metabolic, and Signaling Interactions in PAH

This study examines the hormonal, metabolic, and cellular signaling patterns in people with pulmonary arterial hypertension (PAH) — high blood pressure in the lungs — to understand why the disease develops and why it affects women more often than men. **You may be eligible if...** - You have been diagnosed with idiopathic, heritable, or associated pulmonary arterial hypertension (or are a family member of someone with these diagnoses) - You are generally between 0 and 90 years old (specific sub-studies have narrower age ranges) - You have access to the clinic for testing and can tolerate fasting before some tests (for certain sub-studies) **You may NOT be eligible if...** - You have a different type of diagnosis unrelated to PAH - You exceed the age limits for the specific sub-study - You are unable to fast or travel to the clinic as needed Talk to your doctor to see if this trial is right for you.