Glufosfamide Versus 5-FU in Second Line Metastatic Pancreatic Cancer

This study is comparing a drug called glufosfamide with the standard chemotherapy drug 5-fluorouracil (5-FU) as a second treatment option for patients with advanced pancreatic cancer whose disease has continued to grow after the first treatment. **You may be eligible if...** - You have been diagnosed with pancreatic cancer that has spread to other parts of the body (metastatic) - You have already received one prior chemotherapy treatment and your cancer continued to grow - You are in reasonably good health and able to carry out daily activities - Your liver, kidney, and blood counts are within acceptable ranges - You are at least 18 years old **You may NOT be eligible if...** - You have received two or more prior chemotherapy regimens for pancreatic cancer - You have serious uncontrolled infections or other serious medical conditions - You are pregnant or breastfeeding - You have significant nerve damage from prior chemotherapy - You have brain metastases (cancer that has spread to the brain) - You have had a prior allergic reaction to similar drugs Talk to your doctor to see if this trial is right for you.