RecruitingPhase 3NCT02025023

Local 5-Fluorouracil Injection for the Treatment of Chalazia: A Prospective, Comparative Study


Sponsor

University of Washington

Enrollment

120 participants

Start Date

Dec 1, 2013

Study Type

INTERVENTIONAL

Conditions

Summary

Local injection of 5-fluorouracil into a chalazion (stye) is as effective as local injection of triamcinolone (steroid) and incision and curettage for treatment of chalazia.


Eligibility

Min Age: 18 Years

Inclusion Criteria1

  • Single or multiple chalazia in a single eyelid

Exclusion Criteria1

  • Chalazia present for less than one month and no previous injection or incision and curettage

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Interventions

DRUG5-fluorouracil Injection

If the chalazion is present at follow-up visit, another injection of 5-FU will be given.

DRUGTriamcinolone Acetonide

If chalazion present at follow-up, another Triamcinolone injection will be done.

PROCEDUREIncision and Curettage

If chalazion present at follow-up visit, patient will be randomized to receive local injection of either triamcinolone, 5-FU, or triamcinolone/5-FU mixture.

DRUGTriamcinolone Acetonide/5-fluorouracil mixture

If chalazion persists at follow-up visit, another injection of triamcinolone/5-FU mixture will be done.


Locations(1)

University of Washington Eye Institute at Harborview

Seattle, Washington, United States

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NCT02025023


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