Effect of Different Concentrations of Sevoflurane for Anesthesia Induction in Pediatric Ophthalmic Surgery
Effectiveness and Safety of 6% Versus 8% Sevoflurane for Anesthesia Induction in Pediatric Ophthalmic Minor Surgery: A Randomized Controlled Trial
Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong
80 participants
Feb 25, 2025
INTERVENTIONAL
Conditions
Summary
This randomized controlled trial aims to compare the effectiveness and safety of 6% versus 8% sevoflurane inhalation induction in pediatric patients undergoing minor ophthalmic surgery. The primary outcome is emergence agitation assessed using the Pediatric Anesthesia Emergence Delirium (PAED) scale. Secondary outcomes include hemodynamic parameters, induction time, recovery time, and adverse events.
Eligibility
Inclusion Criteria5
- Children aged 1 to 6 years (12-72 months)
- Scheduled to undergo minor ophthalmic surgery (e.g., chalazion excision) under general anesthesia
- American Society of Anesthesiologists (ASA) physical status I
- Assessed as suitable for inhalation anesthesia by anesthesiologists
- Written informed consent obtained from parents or legal guardians
Exclusion Criteria9
- ASA physical status II or higher
- Known hepatic or renal dysfunction
- Congenital heart disease
- History of malignant hyperthermia
- Known allergy to sevoflurane
- History of asthma or severe respiratory disease
- Upper respiratory tract infection within the past 4 weeks
- Anticipated difficult airway
- Refusal of participation by parents or legal guardians
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
Sevoflurane inhalation anesthesia was used for induction and maintenance of general anesthesia in pediatric patients undergoing minor ophthalmic surgery.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07450495