RecruitingPhase 4NCT02118467

Vasoactive Drugs in Intensive Care Unit

A Randomized Double Blind Trial of Vasoactive Drugs for the Management of Shock in the ICU

Sponsor

University of Chicago

Enrollment

836 participants

Start Date

May 15, 2014

Study Type

INTERVENTIONAL

Conditions

Shock

Summary

The investigators hypothesis is that for ICU patients with shock, the use of the vasoactive drugs phenylephrine and vasopressin will reduce tachydysrhythmias when compared to norepinephrine and epinephrine. To investigate this hypothesis, the investigators are conducting a randomized double blind controlled trial comparing phenylephrine and vasopressin vs. norepinephrine and epinephrine in ICU patients with shock that is not responsive to IV fluids. All patients admitted to the adult intensive care units at the University of Chicago will be screened for eligibility.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This trial is studying different types of medications that raise blood pressure — called vasoactive drugs — used in the intensive care unit (ICU) to treat patients who are in shock. Shock is a life-threatening condition where blood pressure drops so low that organs are not getting enough oxygen. The study aims to find which drug or combination of drugs works best and is safest. **You may be eligible if...** - You are 18 or older - You are currently in an intensive care unit being treated for shock - Your blood pressure remains dangerously low even after you have received intravenous fluids - You need blood pressure–raising medications delivered through a central intravenous line (a line inserted into a large vein) **You may NOT be eligible if...** - Your heart has stopped (cardiac arrest) - You are pregnant - You have severe failure of the right side of your heart Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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