Effects of Increasing Mean Arterial Pressure on Renal Function in Patients With Shock and With Elevated Central Venous Pressure
Effects of Increasing Mean Arterial Pressure on Renal Function in Patients With Shock and With Elevated Central Venous Pressure : a Pilot Study for the Individualization of Mean Arterial Pressure
University Hospital, Angers
30 participants
Jan 2, 2023
INTERVENTIONAL
Conditions
Summary
The purpose of this study is to assess the effect of a higher mean arterial pressure on renal function for patients with shock and elevated central venous pressure.
Eligibility
Inclusion Criteria5
- Adult patients (≥ 18 years old )
- Arterial hypotension requiring the etablishment of catecholamines
- Norepinephrine dose ⩾ 0.1µg/kg/min at the inclusion
- High central venous pressure ≥ 12mmHg
- Cardiac output monitoring (PICCO or Swan Ganz)
Exclusion Criteria7
- Anuria
- Patient with an emergency indication of renal replacement therapy (severe hyperkalemia, severe metabolical acidosis with pH <7.15, acute pulmonary edema due to fluid overload resulting in severe hypoxemia, serum urea concentration > 40 mmol/l)
- Pregnant, lactating or parturient woman
- Patient deprived of liberty by judicial or administrative decision
- Patient with psychiatric compulsory care
- Patient subject to legal protection measures
- Patients with do-no-reanimate order or withdrawal of life sustaining support
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Interventions
Increase of mean arterial pressure at 65-70 mmHg (with catecholamines or volemic expansion at the discretion of the clinician)
Increase of mean arterial pressure at 80-85mmHg (with catecholamines or volemic expansion at the discretion of the clinician).
Locations(2)
View Full Details on ClinicalTrials.gov
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NCT05655065