RecruitingNCT02132741

Optical Coherence Tomography And NEphropathy: The OCTANE Study

Assessment of Retinal Vasculature Using Optical Coherence Tomography in Health, Hypertension & Chronic Kidney Disease.

Sponsor

University of Edinburgh

Enrollment

150 participants

Start Date

May 16, 2014

Study Type

OBSERVATIONAL

Conditions

Hypertension Chronic Kidney Disease Health

Summary

Patients with high blood pressure (hypertension) and chronic kidney disease are at an increased risk of developing heart disease and strokes. Part of this risk is due to changes in the structure and function of the blood vessels throughout the body. It is thought that reducing high blood pressure and treating chronic kidney disease improves the structure and function of blood vessels but information on this is limited. Optical coherence tomography (OCT) is a method of looking at the blood vessels at the back of the eye. It is a simple, quick and non-invasive test that you may have previously had during a visit to the optician. The purpose of the study is to ascertain whether OCT is able to detect changes in the eye's blood vessels in patients with hypertension and chronic kidney disease compared to healthy individuals and also to see if any differences seen improve with treatment.

Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This is the OCTANE study — a research study using a special eye scan called Optical Coherence Tomography (OCT) to examine whether changes visible in the tiny blood vessels at the back of the eye (the retina) can serve as an early warning sign of kidney disease in people with high blood pressure or chronic kidney disease. **You may be eligible if...** - You are between 18 and 80 years old - You have high blood pressure (diagnosed or being treated for it) - You have chronic kidney disease (CKD) - Your body mass index (BMI) is 35 or below **You may NOT be eligible if...** - You have a known eye disease or have had eye surgery - You have a refractive error (glasses prescription) stronger than +/- 6 diopters - You have donated blood in the last 4 weeks - You have a history of drug or alcohol abuse - You have participated in another clinical trial in the past month - You are at high risk for HIV or hepatitis B Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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