RecruitingNCT06297291

Global Paradise System US Post Approval Study

The Global Paradise® System US Post Approval Study (US GPS)


Sponsor

ReCor Medical, Inc.

Enrollment

1,000 participants

Start Date

Jun 28, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

The objective of the Global Paradise® System US Post Approval Study (US GPS) is to evaluate the real-world use of the Paradise Ultrasound Renal Denervation System indicated for patients who are unable to lower their blood pressure with lifestyle changes and medication. This system is comprised of a catheter, cable, balloon, and generator and has received FDA approval in the United States. Information collected in this study will be analyzed to better understand the long-term safety and effectiveness of treatment with the Paradise System for patients with high blood pressure.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study follows patients who undergo renal denervation using the Paradise System — a procedure that uses ultrasound energy delivered through the kidney arteries to lower blood pressure — to track real-world long-term outcomes. **You may be eligible if...** - You have a documented history of high blood pressure and are on blood pressure medications - Your seated office blood pressure is 140 mmHg or higher and your home blood pressure is 135 mmHg or higher - Your kidneys are functioning adequately (eGFR at least 30) - You are 18 or older **You may NOT be eligible if...** - Your kidney arteries are not suitable for the procedure (wrong size, stented, aneurysm, or narrowed) - You are pregnant - You have a transplanted kidney - You have a tumor on your kidney or adrenal gland - You have conditions that would block catheter access Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEParadise Ultrasound Renal Denervation Treatment

The Paradise Ultrasound Renal Denervation System (Paradise Ultrasound RDN) is an FDA-approved catheter-based system to treat hypertension by ablating the nerves around the renal arteries, disrupting the overactive sympathetic nerves that can cause high blood pressure. The Paradise procedure uses ultrasound energy to calm the nerves near the kidneys to help lower blood pressure. Treatment is usually done in an outpatient setting and typically takes about an hour to perform. As a part of the treatment, a small flexible tube (catheter) is guided into the blood vessels near the kidneys and 7 seconds of ultrasound energy is applied 2-3 times. Both sides are treated and then the catheter is removed, leaving nothing behind. After the procedure, some people go home the same day or some stay overnight.


Locations(38)

Sutter Institute for Medical Research

Sacramento, California, United States

UC Davis Medical Center

Sacramento, California, United States

Pacific Heart Institute

Santa Monica, California, United States

Rocky Mountain Regional VAMC

Aurora, Colorado, United States

Bridgeport Hosptial

Bridgeport, Connecticut, United States

The Cardiac & Vascular Institute

Gainesville, Florida, United States

University of Miami Health System

Miami, Florida, United States

Ascension Sacred Heart

Pensacola, Florida, United States

Tampa Cardiovascular Interventions and Research

Tampa, Florida, United States

Southern Illinois University, Memorial Medical Center

Springfield, Illinois, United States

Ascension via Christi St. Francis

Wichita, Kansas, United States

Touro Infirmary

New Orleans, Louisiana, United States

Massachusetts General Hospital

Boston, Massachusetts, United States

The Brigham and Women's Hospital

Boston, Massachusetts, United States

Henry Ford Health

Detroit, Michigan, United States

Metropolitan Heart & Vascular Institute

Coon Rapids, Minnesota, United States

Saint Luke's Mid America Heart Institute

Kansas City, Missouri, United States

Virtua Health

Marlton, New Jersey, United States

Albany Medical Center

Albany, New York, United States

NewYork-Presbyterian Brooklyn Methodist Hospital

Brooklyn, New York, United States

University at Buffalo

Buffalo, New York, United States

NYU Langone Health - Bellevue Hosptial

New York, New York, United States

Columbia University Medical Center/New York Presbyterian Hospital

New York, New York, United States

Stony Brook Medicine

Stony Brook, New York, United States

University of North Carolina at Chapel Hill School of Medicine

Chapel Hill, North Carolina, United States

Durham VA Health System

Durham, North Carolina, United States

UPMC Harrisburg

Harrisburg, Pennsylvania, United States

Penn Medicine

Phildelphia, Pennsylvania, United States

Medical University of South Carolina

Charleston, South Carolina, United States

Prisma Health Richland Hospital

Columbia, South Carolina, United States

Spartanburg Regional Medical Center

Spartanburg, South Carolina, United States

Ascension Saint Thomas

Nashville, Tennessee, United States

Ascension Seton

Austin, Texas, United States

Dallas VAMC

Dallas, Texas, United States

TCR Institute

Kingwood, Texas, United States

St. Mark's Hospital

Salt Lake City, Utah, United States

Inova Fairfax Hospital

Fairfax, Virginia, United States

Swedish Medical Center

Seattle, Washington, United States

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