RecruitingNot ApplicableNCT02208388
Prospective Evaluation of MyocaRdial PerFUSion ComputEd Tomography Trial
Prospective Evaluation of MyocaRdial PerFUSion ComputEd Tomography Trial: Ischemia-guided Revascularization Using Perfusion Coronary CT vs. Fractional Flow Reserve
Sponsor
Young-Hak Kim, MD, PhD
Enrollment
1,000 participants
Start Date
Aug 12, 2014
Study Type
INTERVENTIONAL
Conditions
Summary
The purpose of this study is to evaluate safety and effectiveness of CTP(computed tomography perfusion) guided revascularization vs FFR(Fractional flow reserve) guided revascularization
Eligibility
Min Age: 20 Years
Inclusion Criteria5
- Age 20 and more
- Diagnosed angina or angina equivalent symptom or positive exercise treadmill test
- Patients with intermediate- or high-risk probability of CAD defined by Diamond and Forester
- % stenosis or more in coronary CTA
- Willing to provide informed, written consent
Exclusion Criteria16
- Requirement for surgical procedure
- Cardiogenic shock and/or need for mechanical/pharmacologic hemodynamic support
- Recent STEMI (<5 days)
- Non STEMI, if the cardiac troponin is not stable or starting to decline
- Left ventricular ejection fraction <30%
- Life expectancy <2 years
- Impaired renal function with an effective glomerular filtration rate less than 30mL/min/1.73 ㎡ or creatinine more than 2.0 mg/dL
- Undergoing evaluation for organ transplantation
- Participation or planned participation in another cardiovascular clinical trial
- Pregnancy
- Inability to take dual antiplatelet therapy for six months
- Previous CABG
- Left main disease requiring revascularization
- Any target lesion with in-stent restenosis
- NYHA class 3 or 4a
- Severe and persistent angina with severe limitation in everyday living activities (Canadian Cardiovascular Society grading Class IV)
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
DEVICEcomputed tomography perfusion guided treatment
DEVICEFractional flow reserve guided treatment
Locations(7)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT02208388
Related Trials
Trial of Orbital Atherectomy Versus Standard Strategy in Calcified Bifurcation Lesions
NCT067368998 locations
Evaluating New Radiation Techniques for Cardiovascular Imaging
NCT016215941 location
Postprocedural Contrast Mediated FFR Plus Intracoronary Infusion of Nitroglycerin in Multivessel Patients (PROMETEUS TRIAL)
NCT062732934 locations
Treatment of Functionally Non-significant Vulnerable Plaques in Patients With Multivessel ST-elevation Myocardial Infarction The VULNERABLE Trial
NCT0559906149 locations
Single vs. Dual Antiplatelet Therapy in Elderly or HBR Patients Undergoing Percutaneous Intervention With DCB (PICCOLETO IV-EPIC 38)
NCT065355681 location