Chemotherapy-induced Cognitive and Brain Changes in Older Adults With Breast Cancer

This trial is studying how chemotherapy affects thinking, memory, and brain structure in older women with breast cancer, to better understand and manage what is sometimes called 'chemo brain.' **You may be eligible if...** - You are a woman aged 60 or older - You have a new diagnosis of invasive breast cancer - Your treatment plan includes chemotherapy - Your life expectancy is at least 1 year - Your general health score (Karnofsky) is 80 or above - You are able to understand and complete questionnaires in English **You may NOT be eligible if...** - You have a prior history of cancer (other than certain skin or cervical cancers) - You have a known neurological condition affecting memory or thinking - You have significant hearing or vision loss that would affect testing - You are already receiving cancer treatment Talk to your doctor to see if this trial is right for you.