RecruitingNCT02456974
Antibiotic Dosing in Pediatric Intensive Care
Sponsor
University Hospital, Ghent
Enrollment
640 participants
Start Date
May 1, 2012
Study Type
OBSERVATIONAL
Conditions
Summary
Pharmacokinetics of antibiotics in critically ill neonates, infants and children
Eligibility
Min Age: 1 DayMax Age: 16 Years
Inclusion Criteria4
- patients admitted to the pediatric intensive care unit
- patient age/weight : 1,8 kg-15 years
- patient receiving antibiotic treatment (piperacillin-tazobactam, amoxicillin-clavulanate, vancomycin, teicoplanin, meropenem, ciprofloxacin, amikacin) via intermittent infusion regimen or continuous infusion according to institutional treatment guidelines
- intra-arterial or intravenous access other than the drug infusion line available for blood sampling (arterial line is preferred)
Exclusion Criteria4
- no catheter in place for blood sampling
- absence of parental/patient consent
- known hypersensitivity to beta-lactam antibiotics, glycopeptides, fluoroquinolones, aminoglycosides
- extracorporeal circuit (haemodialysis, ECMO, peritoneal dialysis )
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Interventions
PROCEDUREblood sampling in patients receiving amoxicillin-clavulanate as part of routine clinical care
PROCEDUREblood sampling in patients receiving piperacilline-tazobactam as part of routine clinical care.
PROCEDUREblood sampling in patients receiving vancomycin as part of routine clinical care.
PROCEDUREblood sampling in patients receiving teicoplanin as part of routine clinical care.
PROCEDUREblood sampling in patients receiving meropenem as part of routine clinical care.
PROCEDUREblood sampling and urine smapling in patients receiving ciprofloxacin as part of routine clinical care.
PROCEDUREblood sampling in patients receiving amikacin as part of routine clinical care.
Locations(1)
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NCT02456974
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