Endocrine Treatment Alone for Elderly Patients With Estrogen Receptor Positive Operable Breast Cancer and Low Recurrence Score

This study is investigating whether older women with early-stage, slow-growing breast cancer can be safely and effectively treated with hormone-blocking pills alone (such as an aromatase inhibitor), without undergoing surgery — particularly for patients whose tumors are estrogen-driven and show low signs of aggressive growth. **You may be eligible if...** - You are 70 years of age or older - You have newly diagnosed early-stage breast cancer that could potentially be removed with surgery (not yet spread to distant organs) - Your cancer is estrogen receptor positive (ER+) and HER2 negative - Your tumor grows slowly (low Ki67 score or low to intermediate growth index) - Your tumor can be measured by ultrasound or mammogram - You are in reasonably good health overall **You may NOT be eligible if...** - You have already had surgery for this cancer - You had another cancer within the past 5 years - You are currently enrolled in another experimental treatment study - You have uncontrolled illness that would prevent safe participation - You have HIV and are on combination antiretroviral therapy Talk to your doctor to see if this trial is right for you.