Pilot Study of (MR) Imaging With Pyruvate (13C) to Detect High Grade Prostate Cancer

This study is testing whether a special MRI scan using a naturally occurring substance (pyruvate, labeled with carbon-13) can accurately detect high-grade prostate cancer before surgery or after a focused treatment called HIFU (high-intensity focused ultrasound). **You may be eligible if...** - You are a man with biopsy-confirmed prostate cancer - You are either scheduled for prostate removal surgery (radical prostatectomy) at UCSF, or you recently had HIFU focal therapy and are scheduled for a follow-up biopsy - You are in good general health (ECOG performance status 0 or 1) - Your blood counts, kidney function, and liver function are within acceptable ranges **You may NOT be eligible if...** - You are under 18 years old or have conditions that prevent you from giving informed consent - You cannot have an MRI (e.g., you have a pacemaker or metal implants) - You are allergic to gadolinium contrast dye or have poor kidney function - You have a latex allergy or prior rectal surgery that prevents use of an endorectal coil (part of the MRI setup) - You have previously had surgery, radiation, or hormone therapy for prostate cancer (HIFU is allowed for one group) - You have uncontrolled high blood pressure, congestive heart failure, or a history of heart attack in the past 6 months Talk to your doctor to see if this trial is right for you.