Feasibility of the LUM Imaging System for Detection of Gastrointestinal Cancers

This study is testing a new imaging system (the LUM Imaging System) that may help surgeons better see the edges of gastrointestinal cancers during surgery by using a special light-activated dye, potentially improving how completely tumors are removed. **You may be eligible if...** - You are 18 years of age or older - You have been confirmed by biopsy to have esophageal, colorectal, or pancreatic cancer (including high-grade precancerous changes) - You are scheduled for surgical removal of the tumor (including endoscopic procedures) - You are in generally good health with adequate blood counts and kidney/liver function - You are willing and able to follow study procedures and have signed the consent form - You may have previously received pre-surgical radiation or chemotherapy **You may NOT be eligible if...** - You have taken an experimental drug within the past 30 days - You are pregnant or breastfeeding - You have uncontrolled high blood pressure - You have a history of allergies to PEG (polyethylene glycol) or IV contrast agents - You are HIV-positive and on antiretroviral therapy - You are sexually active and unwilling to use contraception - Your heart's electrical activity (QTc interval) is abnormally prolonged Talk to your doctor to see if this trial is right for you.