RecruitingNot ApplicableNCT07307560

High-Flow Nasal Cannula for Preventing Hypoxia During Sedated Endoscopy in High-Risk Obstructive Sleep Apnea Patients

High-Flow Nasal Cannula for Preventing Hypoxia During Sedated Endoscopy in High-Risk Obstructive Sleep Apnea Patients: A Multicenter Randomized Trial

Sponsor

Zhejiang University

Enrollment

600 participants

Start Date

Dec 21, 2025

Study Type

INTERVENTIONAL

Conditions

Esophageal Cancer Hypoxia Gastric Cancer (Diagnosis)Obstructive Sleep Apnea (OSA)

Summary

Hypoxia represents the most frequent adverse event during propofol-sedated gastrointestinal endoscopy. The STOP-BANG questionnaire serves as a widely adopted, straightforward tool for screening obstructive sleep apnea (OSA) risk, with a score ≥5 identifying high-risk OSA patients who are particularly susceptible to hypoxia under sedation. Although preliminary research from our team suggests that High-Flow Nasal Cannula (HFNC) may lower the incidence of hypoxemia, evidence remains limited and inconsistent in studies specifically targeting high-risk OSA populations. Therefore, this multicenter randomized controlled trial aims to evaluate whether HFNC can effectively reduce the occurrence of hypoxia during sedated gastrointestinal endoscopy in patients identified as high-risk for OSA.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether using a high-flow nasal cannula (a device that delivers a steady stream of humidified oxygen through the nose) during sedated endoscopy procedures can prevent dangerous drops in blood oxygen levels in patients who are at high risk for sleep apnea. **You may be eligible if...** - You are 18 or older - You have a STOP-Bang score of 5 or higher (a screening score suggesting high risk for obstructive sleep apnea) - You are scheduled for a sedated gastrointestinal endoscopy (stomach scope, colonoscopy, or both) lasting 45 minutes or less - You have signed the informed consent form **You may NOT be eligible if...** - You have a clotting disorder or bleeding tendency in the mouth or nose - You have an active upper respiratory tract infection - You have other conditions that make this device unsafe or impractical Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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