Aging, Geriatric Syndromes and Clonal Hematopoiesis
Washington University School of Medicine
2,000 participants
Mar 10, 2016
OBSERVATIONAL
Conditions
Summary
In this study the investigators will incorporate a wide range of clinical variables associated with aging and cardiovascular disease to determine whether they are associated with mutation status independent of chronologic age. Clinically, aging can be operationalized using geriatric assessment, which entails a comprehensive multi-dimensional assessment of the health of an older adult, including measures of comorbidity, polypharmacy, functional status, cognition, depression, falls, social activities and social support. Given that aging is heterogeneous, geriatric assessment allows greater specificity for aging than chronological age alone.
Eligibility
Plain Language Summary
Simplified for easier understanding
This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.
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Interventions
-Baseline and no more frequently than every 6 months until death
* 10 items about daily functional status * Baseline and no more frequently than every 6 months until death
* 7 items about daily functional status * Baseline and no more frequently than every 6 months until death
* 1 item about daily functional status * Baseline and no more frequently than every 6 months until death
* 1 item about daily functional status * Baseline and no more frequently than every 6 months until death
* 13 items about comorbidity * Baseline and no more frequently than every 6 months until death
* 4 items about social activity * Baseline and no more frequently than every 6 months until death
* 2 items about nutrition * Baseline and no more frequently than every 6 months until death
-Baseline and no more frequently than every 6 months until death
* Participants will rinse their mouths 2 times with water for 20-30 seconds and discard the expectorated sample. One side of the inner cheek (buccal mucosa) will then be scraped with a cotton swab 20 times (alternatively, the tongue will be brushed 20 times with a toothbrush) * Baseline and no more frequently than every 6 months until death
* 7 items about heart health and smoking history * Baseline and no more frequently than every 6 months until death
* Research coordinator will test gait speed * Baseline and no more frequently than every 6 months until death
* Research coordinator will test grip strength * Baseline and no more frequently than every 6 months until death
-Baseline and no more frequently than every 6 months until death
-Baseline and no more frequently than every 6 months until death
-1 optional bone marrow biopsy
-For Arm E only
Hip replacement participants only
Knee replacement participants only
Hip and knee replacement participants only
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT02604563