TREAT-BE Study (Treatment With Resection and Endoscopic Ablation Techniques for Barrett's Esophagus)

This study is comparing two ways to treat Barrett's esophagus with early-stage cancer: (1) surgery to remove part of the esophagus, or (2) a combination of endoscopic procedures (non-surgical treatments done with a camera through the mouth) to remove the abnormal tissue. **You may be eligible if...** - You have Barrett's esophagus (a condition where the lining of the esophagus changes) with early-stage cancer or pre-cancerous changes - Your cancer is confined to the top layers of the esophagus and has not spread deeper or to lymph nodes - You are healthy enough to undergo either surgery or endoscopic treatment - Your doctor has confirmed through imaging and tissue sampling that you meet the criteria **You may NOT be eligible if...** - Your cancer has grown deeper into the esophagus wall or spread to lymph nodes - You have had previous treatment for this condition - You have other serious health conditions that make either procedure unsafe - You are pregnant Talk to your doctor to see if this trial is right for you.