RecruitingNCT02638142

Loop Diuretic Therapy in Acutely Decompensated Heart Failure

Continuous Versus Bolus Intermittent Loop Diuretic Infusion in Acutely Decompensated Heart Failure: Evaluation of Renal Function, Congestion Signs, BNP and Outcome

Sponsor

University of Siena

Enrollment

370 participants

Start Date

Dec 1, 2015

Study Type

OBSERVATIONAL

Conditions

Acute Heart Failure

Summary

DiurHF is a prospective, multicenter, observational, study that compares continuous with intermittent infusion of furosemide in patients admitted with a diagnosis of ADHF. Previous pilot study design was planned to anticipate a larger multicenter trial able to definitively evaluate the optimal loop diuretic use strategy in patients with ADHF.

Eligibility

Min Age: 18 Years

Inclusion Criteria4

Patients over 18 years;
Patients with diagnosis of ADHF(dyspnea, orthopnea, peripheral edema or major fatigue and at least two clinical signs including rales, hepatomegaly, pulmonary congestion on chest radiography, jugular vein dilatation, or a third heart sound);
Blood BNP \> 100 pg/mL;
ADHF: Acute Decompensated Heart Failure; BNP: B-type Natriuretic Peptide; IV: IntraVenous; LVEF: Left Ventricular Ejection Fraction.

Exclusion Criteria6

Patients who receive more than 40 mg of IV furosemide;
End-Stage renal disease or renal replacement therapy;
Recent myocardial infarction (within thirty days of screening);
Systolic blood pressure \< 80 mmHg;
Creatinine levels \> 4 mg/dL;
Patients affected by sepsis, liver diseases, inflammatory diseases or neoplastic diseases.