RecruitingNCT02638142

Loop Diuretic Therapy in Acutely Decompensated Heart Failure

Continuous Versus Bolus Intermittent Loop Diuretic Infusion in Acutely Decompensated Heart Failure: Evaluation of Renal Function, Congestion Signs, BNP and Outcome


Sponsor

University of Siena

Enrollment

370 participants

Start Date

Dec 1, 2015

Study Type

OBSERVATIONAL

Conditions

Summary

DiurHF is a prospective, multicenter, observational, study that compares continuous with intermittent infusion of furosemide in patients admitted with a diagnosis of ADHF. Previous pilot study design was planned to anticipate a larger multicenter trial able to definitively evaluate the optimal loop diuretic use strategy in patients with ADHF.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at the best way to give water pills (diuretics) to patients who are in the hospital with a sudden worsening of heart failure — comparing giving the medicine continuously through an IV versus giving it in separate doses throughout the day. **You may be eligible if...** - You are admitted to the hospital with sudden worsening of heart failure (fluid buildup causing shortness of breath or swelling) - You require IV diuretic (water pill) therapy to remove excess fluid - You are over 18 years old **You may NOT be eligible if...** - You are in kidney failure or your kidneys are not functioning adequately - You are in a life-threatening emergency requiring immediate intensive care - You have very low blood pressure - You have a specific cause of heart failure (like a blocked artery requiring urgent intervention) - You are allergic to the study medications - You are pregnant Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGContinuous Furosemide Infusion

Intravenous continuous Furosemide infusion

DRUGIntermittent Furosemide Infusion

Intravenous bolus intermittent Furosemide Infusion


Locations(4)

Ospedale Madonna della Navicella

Chioggia, Venezia, Italy

Azienda Ospedaliera di Padova

Padova, Italy

University of Rome La Sapienza

Roma, Italy

Department of Internal Medicine, Cardiovascular Diseases Unit

Siena, Italy

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NCT02638142


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