Infliximab Therapy for Dolichoectactic Vertebrobasilar Aneurysms

This study is testing whether a drug called infliximab (commonly used for autoimmune diseases like Crohn's disease and rheumatoid arthritis) can stabilize or shrink abnormally enlarged and twisted blood vessels at the base of the brain (called dolichoectatic vertebrobasilar aneurysms), which can cause strokes. **You may be eligible if...** - You have been diagnosed with a dolichoectatic vertebrobasilar aneurysm (an abnormally enlarged, elongated, and twisted artery at the base of the brain) - You have had a stroke or symptoms related to this condition - You are not a candidate for standard surgical or interventional treatment - You are in overall stable health **You may NOT be eligible if...** - You have an active infection (including tuberculosis) - You have a history of certain cancers - You have serious heart failure - You are pregnant or breastfeeding - You have already had a severe allergic reaction to infliximab or similar drugs - You are taking certain medications that could interact with infliximab Talk to your doctor to see if this trial is right for you.