RecruitingNCT02670031

Response of the Myocardium to Hypertrophic Conditions in the Adult Population

Sponsor

National Heart Centre Singapore

Enrollment

2,000 participants

Start Date

Jan 1, 2016

Study Type

OBSERVATIONAL

Conditions

Hypertension Left Ventricular Hypertrophy Myocardial Fibrosis

Summary

Hypertension and aortic stenosis are the two leading conditions that cause thickening of the heart muscles (left ventricular hypertrophy). Left ventricular hypertrophy is initially adaptive to maintain optimal heart function. Ultimately, heart failure occurs as a result of progressive muscle cell death and scarring (myocardial fibrosis). Dedicated techniques using cardiovascular magnetic resonance imaging (MRI) and novel high-sensitivity cardiac troponin blood assays are potential markers to detect myocardial fibrosis. Although hypertension-related heart disease is very common in Singapore, the significance of myocardial fibrosis is not well understood. In this study, the significance of myocardial fibrosis in 2000 patients with hypertension would be investigated. This will be the largest study using state-of-the-art MRI to examine the importance of myocardial fibrosis in hypertensive heart disease. 1000 participants, with at least 1 year follow-up, will be invited for a repeat assessment.

Eligibility

Min Age: 21 YearsMax Age: 99 Years

Plain Language Summary

Simplified for easier understanding

This study is researching how the heart muscle responds and adapts when it is under extra strain (such as in high blood pressure or heart valve disease), specifically looking at changes in heart muscle cells and structure to understand when and why the heart starts to fail. **You may be eligible if...** - You have a condition causing the heart to work harder than normal, such as high blood pressure, heart valve disease, or another condition that causes the heart to enlarge - You are scheduled for a heart procedure (such as valve replacement surgery) during which heart tissue samples can be safely collected - You are in adequate health to undergo the scheduled procedure **You may NOT be eligible if...** - You have a serious systemic illness unrelated to your heart condition - You are pregnant - You are unwilling to have tissue samples taken during your procedure - Your heart condition is too advanced to safely participate Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERCardiovascular Magnetic Resonance

For the evaluation of left ventricular volumes, function and mass. This is also for the assessment of myocardial fibrosis based on delayed enhancement imaging technique.

OTHEREchocardiogram

For the assessment of diastolic and systolic function as well as valvular and cardiac function. Ventricular-arterial coupling will also be performed.

OTHERElectrocardiogram

To examine specific function of the heart.

DEVICEAmbulatory Blood Pressure Monitoring

A 24-hour test.

OTHERRetinal Photography (Optional)

The test studies the structure and function of the eye vessels. It involves using eye drops to dilate the pupils, allowing the retinal photographer to have a better view of the back of the eye.