Xenon-129 and Inert Fluorinated Gas Lung MRI: Study of Healthy Volunteers and Participants With Pulmonary Disease

This study is using special MRI scans with inhaled gases (xenon-129 and a fluorinated gas) to create detailed images of how air moves through the lungs, helping researchers better understand conditions like asthma, cystic fibrosis, and COPD. **You may be eligible if...** - You are 8 years or older - You have no smoking history - If you have asthma or cystic fibrosis, your symptoms are at your usual stable level - Your lung function (measured by a breathing test) is above 40% of predicted normal - You are able to hold your breath for up to 20 seconds - You can perform consistent, reproducible breathing tests **You may NOT be eligible if...** - You are a current or former smoker - Your lung function is severely reduced (below 40% of predicted) - You cannot hold your breath or cooperate with the breathing tests - You have conditions that make MRI scanning unsafe Talk to your doctor to see if this trial is right for you.