CINSARC Signature and Correlation With Hemotherapy Efficacy in Soft-tissue Sarcomas. A Biomarker Study.

This study is testing whether a genetic test called the CINSARC signature — which looks at specific patterns of gene activity in a tumor — can predict which patients with soft tissue sarcoma (cancer of connective tissues like muscle or fat) will respond well to chemotherapy given before surgery. **You may be eligible if...** - You have been diagnosed with soft tissue sarcoma, confirmed by specialist pathology review - Your cancer has not spread to distant parts of the body - Your medical team recommends chemotherapy before surgery to shrink the tumor - You are 18 years or older and in good general health - You have frozen tumor tissue available, or you are willing to have a biopsy - Your cancer is measurable on imaging scans **You may NOT be eligible if...** - Your sarcoma has already spread elsewhere in the body - You are too unwell to receive chemotherapy - You are pregnant or breastfeeding - Your tumor was previously irradiated and is the only measurable site Talk to your doctor to see if this trial is right for you.