RecruitingNCT02812290

Diagnostic and Therapeutic Applications of Microarrays in Lung Transplantation

Multi-Centric Observational Study to Analyze the Diagnostic Molecular Features in the Clinical Setting of Lung Allograft Biopsies

Sponsor

University of Alberta

Enrollment

700 participants

Start Date

May 1, 2016

Study Type

OBSERVATIONAL

Conditions

Lung Transplant Rejection

Summary

Objective: To evaluate the potential impact of molecular phenotyping of transbronchial biopsies in lung transplant recipients with allograft dysfunction, and the potential for developing a safer endobronchial mucosal biopsy format.

Eligibility

Min Age: 18 Years

Inclusion Criteria1

All lung transplant recipients undergoing a biopsy as determined by their surgeon or physician.

Exclusion Criteria1

Patients who declined participation or unable to give informed consent.

Print for Your Doctor

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

PROCEDURELung transplant biopsy bites.

In the second phase of the study, two biopsy bites from the same patient will be collected to assess tissue sampling variability.

Locations(11)

St. Joseph's Hospital and Medical Center 350 West Thomas Road, Floor 8HLT

Phoenix, Arizona, United States

University of Maryland School of Medicine

Baltimore, Maryland, United States

Division of Pulmonary and Critical Care, Washington University School of Medicine

St Louis, Missouri, United States

University of Texas at San Antonio

San Antonio, Texas, United States

The Alfred Hospital, Monash University

Melbourne, Australia

Department of Thoracic Surgery, Medical University of Vienna

Vienna, Austria

Alberta Transplant Applied Genomics Centre, University of Alberta

Edmonton, Alberta, Canada

Department of Medicine, University of Alberta

Edmonton, Alberta, Canada

University Health Network, Toronto General Hospital

Toronto, Ontario, Canada

Charles University/Hospital Motol

Prague, Czechia

Thoracic Surgery Transplant Clinic

Szczecin, Poland

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT02812290

Related Trials

A Study to Test How Effective Belumosudil Tablets Are for Treating Adult Participants With Chronic Lung Allograft Dysfunction

NCT0608203780 locations

Developing Hyperpolarized Gas MRI Signatures to Detect and Manage Acute Cellular Rejection

NCT070469101 location

Prospective Multicenter Research on Donor and Recipient Management Strategies to Improve Lung Transplant Outcomes

NCT0639930217 locations

Cryoprobe Biopsy and Chronic Rejection in Lung Transplant Recipients

NCT068244021 location

Safety of Endobronchial Mesenchymal Stromal Cells in the Treatment of Chronic Lung Allograft Dysfunction

NCT065143781 location