RecruitingNCT02812290

Diagnostic and Therapeutic Applications of Microarrays in Lung Transplantation

Multi-Centric Observational Study to Analyze the Diagnostic Molecular Features in the Clinical Setting of Lung Allograft Biopsies

Sponsor

University of Alberta

Enrollment

700 participants

Start Date

May 1, 2016

Study Type

OBSERVATIONAL

Conditions

Lung Transplant Rejection

Summary

Objective: To evaluate the potential impact of molecular phenotyping of transbronchial biopsies in lung transplant recipients with allograft dysfunction, and the potential for developing a safer endobronchial mucosal biopsy format.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study applies advanced molecular testing (microarrays) to biopsy samples from lung transplant patients to better diagnose rejection and infections after transplantation. The goal is to develop more accurate diagnostic tools to monitor lung transplant health and guide treatment decisions. You may be eligible if: - You are 18 years or older - You have received a lung transplant - Your surgeon or physician has determined that a biopsy is needed as part of your clinical care You may NOT be eligible if: - You declined to participate in the study - You are unable to give informed consent Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDURELung transplant biopsy bites.

In the second phase of the study, two biopsy bites from the same patient will be collected to assess tissue sampling variability.

Locations(11)

St. Joseph's Hospital and Medical Center 350 West Thomas Road, Floor 8HLT

Phoenix, Arizona, United States

University of Maryland School of Medicine

Baltimore, Maryland, United States

Division of Pulmonary and Critical Care, Washington University School of Medicine

St Louis, Missouri, United States

University of Texas at San Antonio

San Antonio, Texas, United States

The Alfred Hospital, Monash University

Melbourne, Australia

Department of Thoracic Surgery, Medical University of Vienna

Vienna, Austria

Alberta Transplant Applied Genomics Centre, University of Alberta

Edmonton, Alberta, Canada

Department of Medicine, University of Alberta

Edmonton, Alberta, Canada

University Health Network, Toronto General Hospital

Toronto, Ontario, Canada

Charles University/Hospital Motol

Prague, Czechia

Thoracic Surgery Transplant Clinic

Szczecin, Poland

View Full Details on ClinicalTrials.gov

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NCT02812290

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